Cytogenetic abnormalities in b-immunoblastic lymphoma

Marcus B. Nashelsky, Michelle M. Hess, Dennis D. Weisenburger, Jene L. Pierson, Martin A. Bast, James O. Armitage, Warren G. Sanger

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We have considered the cytogenetic abnormalities present in 27 unpublished cases of B-immunoblastic lymphoma. Among these 27 patients, the chromosome changes were heterogeneous and complex. The chromosomes most commonly gained were 3 (44% of cases), 18 (44% 6 (30% and 11 (30% The most common structural abnormalities involved band 14q32 (26% band 18q21 (15% and bands 6q 16-21 (19% Study of these 27 immunoblastic lymphomas did not allow us to tentatively identify a common primary cytogenetic abnormality unique to B-immunoblastic lymphoma, however, a translocation at 14q32 may be the primary cytogenetic lesion in some of the cases. Rather, we have added to the number of abnormalities reported in immunoblastic lymphoma and in non-Hodgkin's lymphoma in general.

Original languageEnglish (US)
Pages (from-to)415-420
Number of pages6
JournalLeukemia and Lymphoma
Volume14
Issue number5-6
DOIs
StatePublished - 1994

Keywords

  • B-immunoblastic lymphoma
  • Chromosomes
  • Lymphoma
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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