TY - JOUR
T1 - Cytogenetic abnormalities in noncutaneous peripheral T-cell lymphoma
AU - Sanger, Warren G.
AU - Weisenburger, Dennis D.
AU - Armitage, James O.
AU - Purtilo, David T.
N1 - Funding Information:
Supported in part by PHS Grant no. CA-30196 from the National Cancer Institute, DHHS, Grant LB506 from the Nebraska State Department of Health, the Lymphoproliferative Research Fund, and the Cytogenetics Development Fund.
PY - 1986/9
Y1 - 1986/9
N2 - Cytogenetic studies were performed on lymph nodes from eight patients with noncutaneous peripheral T-cell lymphoma. At least one chromosomally abnormal clone was identified in each patient. Chromosomes having structural abnormalities in two or more patients included chromosome #1 (four), chromosome #2 (three), chromosome #4 (two), chromosome #8 (two), chromosome #14 (two), and chromosome #17 (two). The abnormal clones from seven patients had structural abnormalities involving either chromosomes #1 or #2, and the eighth patient had an abnormal clone that was trisomic for chromosome #1. We did not observe structural rearrangements in chromosome #14 at bands q11 or q12 in any of our cases, in contrast to previous suggestions that this chromosomal region may play a critical role in the development of T-cell lymphomas. Our findings suggest that other nonrandom chromosome abnormalities are common and may be important in the development of non-cutaneous peripheral T-cell lymphomas.
AB - Cytogenetic studies were performed on lymph nodes from eight patients with noncutaneous peripheral T-cell lymphoma. At least one chromosomally abnormal clone was identified in each patient. Chromosomes having structural abnormalities in two or more patients included chromosome #1 (four), chromosome #2 (three), chromosome #4 (two), chromosome #8 (two), chromosome #14 (two), and chromosome #17 (two). The abnormal clones from seven patients had structural abnormalities involving either chromosomes #1 or #2, and the eighth patient had an abnormal clone that was trisomic for chromosome #1. We did not observe structural rearrangements in chromosome #14 at bands q11 or q12 in any of our cases, in contrast to previous suggestions that this chromosomal region may play a critical role in the development of T-cell lymphomas. Our findings suggest that other nonrandom chromosome abnormalities are common and may be important in the development of non-cutaneous peripheral T-cell lymphomas.
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U2 - 10.1016/0165-4608(86)90149-4
DO - 10.1016/0165-4608(86)90149-4
M3 - Article
C2 - 3488804
AN - SCOPUS:0022918887
SN - 0165-4608
VL - 23
SP - 53
EP - 59
JO - Cancer genetics and cytogenetics
JF - Cancer genetics and cytogenetics
IS - 1
ER -