Cytogenetic and pathologic aspects of Ewing's sarcoma and neuroectodermal tumors

Christine F. Stephenson, Julia A. Bridge, Avery A. Sandberg

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Diagnostic classification of poorly differentiated, round cell, primitive neuroectodermal neoplasms, including Ewing's sarcoma, peripheral neuroepithelioma, Askin's tumor, and esthesioneuroblastoma, is challenging to the surgical pathologist using conventional histopathologic approaches because of very similar and overlapping morphologic and cytologic features. Furthermore, distinguishing these noeplasms from neuroblastoma, embryonal rhabdomyosarcoma, small cell osteogenic sarcoma, and non-Hodgkin's lymphoma can be difficult. This paper describes and reviews the cytogenetic and molecular genetic changes in these tumors and demonstrates how the ability to detect these changes has enabled a greater understanding of the histogenesis, classification, diagnosis, and prognosis of these neoplasms.

Original languageEnglish (US)
Pages (from-to)1270-1277
Number of pages8
JournalHuman Pathology
Issue number11
StatePublished - Nov 1992

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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