Cytogenetic surveillance of tobacco-areca nut (mava) chewers, including patients with oral cancers and premalignant conditions

Siddharth G. Adhvaryu, Bhavana J. Dave, Amit H. Trivedi

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Three cytogenetic endpoints were studied in non-chewing healthy controls and 3 groups of tobacco-areca nut chewers, viz. normal chewers, chewers with oral submucous fibrosis and chewers with oral cancer. Frequencies of sister-chromatid exchanges and chromosome aberrations in peripheral blood lymphocytes and of micronucleated cells in exfoliated buccal mucosa were evaluated. All the parameters showed statistically significant elevations in all 3 groups of chewers compared to the controls. The data indicate possible application of the parameters as sensitive endpoints for monitoring tobacco-areca nut chewers, the group of individuals at higher risk of developing oral cancer, the commonest cancer among Indian males.

Original languageEnglish (US)
Pages (from-to)41-49
Number of pages9
JournalMutation Research/Genetic Toxicology
Volume261
Issue number1
DOIs
StatePublished - Sep 1991

Keywords

  • Buccal mucosa cells
  • Chromosome aberration
  • Human lymphocytes
  • Micronucleus
  • Sister-chromatid exchange
  • Tobacco plus areca nut (mava) chewing

ASJC Scopus subject areas

  • Toxicology
  • Genetics

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