Cytokine expression and signaling in brain tumors

Nandini Dey, Donald L. Durden, Erwin G. Van Meir

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

This chapter updates previous knowledge on cytokine expression in tumors of the central nervous system (CNS) and adds information relating to specific cytokine receptors and their cognate ligands as possible targets for brain tumor therapeutic modulation [1,2]. Due to space constraints, we focused our discussion and cited references mostly on work done in the last 10 years. Further readings on cytokine expression in relation to normal brain physiology and pathology can be found in other chapters of this book. Lastly, we discuss the potential of intracellular targeting of nonredundant “bottleneck” signaling events within the stromal and tumor microenvironment for more efficacious therapeutic activity in vivo.

Original languageEnglish (US)
Title of host publicationCytokines and the CNS
PublisherCRC Press
Pages194-242
Number of pages49
ISBN (Electronic)9781420039849
ISBN (Print)0849316227, 9780849316227
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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