Cytokines: Promoters and dampeners of autoimmunity

Natasha Hill, Nora Sarvetnick

Research output: Contribution to journalReview articlepeer-review

93 Scopus citations

Abstract

Cytokines are the co-ordinators of the immune system and, as such, are important targets for immunomodulation. Progress has been made towards the use of IL-10 for immunosuppressive therapy to prevent autoimmunity. Interest has also recently focused on the role of cytokines in controlling the activation of dendritic cells and NK cells, and the consequences of this for the development of autoaggressive responses. Genes involved in IFN-activated pathways that control the survival of lymphocytes have been strongly linked to lupus susceptibility, and IFN-mediated defenses against viral infection have been shown to determine susceptibility to a model of viral-induced diabetes.

Original languageEnglish (US)
Pages (from-to)791-797
Number of pages7
JournalCurrent Opinion in Immunology
Volume14
Issue number6
DOIs
StatePublished - Dec 1 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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