TY - JOUR
T1 - Cytokines
T2 - Promoters and dampeners of autoimmunity
AU - Hill, Natasha
AU - Sarvetnick, Nora
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Cytokines are the co-ordinators of the immune system and, as such, are important targets for immunomodulation. Progress has been made towards the use of IL-10 for immunosuppressive therapy to prevent autoimmunity. Interest has also recently focused on the role of cytokines in controlling the activation of dendritic cells and NK cells, and the consequences of this for the development of autoaggressive responses. Genes involved in IFN-activated pathways that control the survival of lymphocytes have been strongly linked to lupus susceptibility, and IFN-mediated defenses against viral infection have been shown to determine susceptibility to a model of viral-induced diabetes.
AB - Cytokines are the co-ordinators of the immune system and, as such, are important targets for immunomodulation. Progress has been made towards the use of IL-10 for immunosuppressive therapy to prevent autoimmunity. Interest has also recently focused on the role of cytokines in controlling the activation of dendritic cells and NK cells, and the consequences of this for the development of autoaggressive responses. Genes involved in IFN-activated pathways that control the survival of lymphocytes have been strongly linked to lupus susceptibility, and IFN-mediated defenses against viral infection have been shown to determine susceptibility to a model of viral-induced diabetes.
UR - http://www.scopus.com/inward/record.url?scp=0036888372&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036888372&partnerID=8YFLogxK
U2 - 10.1016/S0952-7915(02)00403-X
DO - 10.1016/S0952-7915(02)00403-X
M3 - Review article
C2 - 12413531
AN - SCOPUS:0036888372
SN - 0952-7915
VL - 14
SP - 791
EP - 797
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 6
ER -