Cytology adds value to imaging studies for risk assessment of malignancy in pancreatic mucinous cysts

Muriel Genevay, Mari Mino-Kenudson, Kurt Yaeger, Ioannis T. Konstantinidis, Cristina R. Ferrone, Sarah Thayer, Carlos Fernandez Del Castillo, Dushyant Sahani, Brenna Bounds, David Forcione, William R. Brugge, Martha Bishop Pitman

Research output: Contribution to journalArticlepeer-review

115 Scopus citations

Abstract

OBJECTIVE:: Evaluate the value of cytology relative to imaging features in risk assessment for malignancy as defined in the Sendai Guidelines. BACKGROUND:: The Sendai Guidelines list symptoms, cyst size >30 mm, dilated main pancreatic duct (MPD) >6 mm, mural nodule (MN) and "positive" cytology as high risk stigmata for malignancy warranting surgical triage. METHODS:: We reviewed clinical, radiological and cytological data of 112 patients with histologically confirmed mucinous cysts of the pancreas evaluated in a single tertiary medical center. Cytology slides were blindly re-reviewed and epithelial cells grouped as either benign or high-grade atypia (HGA) [high-grade dysplasia]. Histologically, neoplasms were grouped as benign (low-grade and moderate dysplasia) and malignant (in situ and invasive carcinoma). Performance characteristics of cytology relative to other risk factors were evaluated. RESULTS:: Dilated MPD, MN, and HGA were independent predictors of malignancy (p < 0.0001), but not symptoms (p = 0.29) or cyst size >30 mm (p = 0.51). HGA was the most sensitive predictor of malignancy in all cysts (72%) and in small (≤30 mm) branch-duct intraductal papillary mucinous neoplasm (BD IPMN; 67%), whereas also being specific (85 and 88%, respectively). MN and dilated MPD were highly specific (>90%), but insensitive (39%-44%). Cytology detected 30% more cancers in small cysts than dilated MPD or MN and half of the cancers without either of these high-risk imaging features. CONCLUSIONS:: Cytology adds value to the radiological assessment of predicting malignancy in mucinous cysts, particularly in small BD IPMN. Copyright C

Original languageEnglish (US)
Pages (from-to)977-983
Number of pages7
JournalAnnals of surgery
Volume254
Issue number6
DOIs
StatePublished - Dec 2011

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Cytology adds value to imaging studies for risk assessment of malignancy in pancreatic mucinous cysts'. Together they form a unique fingerprint.

Cite this