Abstract
Plant endophytic microorganisms represent a largely untapped resource for new bioactive natural products. Eight polyketide natural products were isolated from a mangrove endophytic fungus Phomosis sp. A818. The structural elucidation of these compounds revealed that they share a distinct feature in their chemical structures, an oxygen-bridged cyclooctadiene core skeleton. The study on their structure–activity relationship showed that the α,β-unsaturated δ-lactone moiety, as exemplified in compounds 1 and 2, was critical to the cytotoxic activity of these compounds. In addition, compound 4 might be a potential agonist of AMPK (5-adenosine monophosphate-activated protein kinase).
Original language | English (US) |
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Article number | 1547 |
Journal | Molecules |
Volume | 22 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2017 |
Keywords
- Cyclooctadiene
- Cytotoxicity
- Endophtic fungus
- Mycoepoxydiene
- Polyketide
ASJC Scopus subject areas
- Analytical Chemistry
- Chemistry (miscellaneous)
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Physical and Theoretical Chemistry
- Organic Chemistry