Daptomycin non-susceptible meticillin-resistant Staphylococcus aureus USA 300 isolate

Madhukiran H. Murthy, Michael E. Olson, Robert W. Wickert, Paul D. Fey, Ziba Jalali

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Daptomycin is a novel bactericidal agent active against Gram-positive pathogens including meticillin-resistant Staphylococcus aureus (MRSA). Our case is unique in the description of an MRSA USA 300 isolate that developed decreased susceptibility to daptomycin during daptomycin and vancomycin therapy. Directed sequencing detected a previously reported mutation in mprF, resulting in a T345A substitution, associated with non-susceptibility to daptomycin.

Original languageEnglish (US)
Pages (from-to)1036-1038
Number of pages3
JournalJournal of Medical Microbiology
Issue number8
StatePublished - Aug 2008

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


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