Daptomycin non-susceptible meticillin-resistant Staphylococcus aureus USA 300 isolate

Madhukiran H. Murthy, Michael E. Olson, Robert W. Wickert, Paul D. Fey, Ziba Jalali

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Daptomycin is a novel bactericidal agent active against Gram-positive pathogens including meticillin-resistant Staphylococcus aureus (MRSA). Our case is unique in the description of an MRSA USA 300 isolate that developed decreased susceptibility to daptomycin during daptomycin and vancomycin therapy. Directed sequencing detected a previously reported mutation in mprF, resulting in a T345A substitution, associated with non-susceptibility to daptomycin.

Original languageEnglish (US)
Pages (from-to)1036-1038
Number of pages3
JournalJournal of Medical Microbiology
Volume57
Issue number8
DOIs
StatePublished - Aug 2008

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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