Data for mitochondrial proteomic alterations in the aging mouse brain

Kelly L. Stauch, Phillip R. Purnell, Lance M. Villeneuve, Howard S Fox

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Mitochondria are dynamic organelles critical for many cellular processes, including energy generation. Thus, mitochondrial dysfunction likely plays a role in the observed alterations in brain glucose metabolism during aging. Despite implications of mitochondrial alterations during brain aging, comprehensive quantitative proteomic studies remain limited. Therefore, to characterize the global age-associated mitochondrial proteomic changes in the brain, we analyzed mitochondria isolated from the brain of 5-, 12-, and 24-month old mice using quantitative mass spectrometry. We identified changes in the expression of proteins important for biological processes involved in the generation of precursor metabolites and energy through the breakdown of carbohydrates, lipids, and proteins. These results are significant because we identified age-associated proteomic changes suggestive of altered mitochondrial catabolic reactions during brain aging. The proteomic data described here can be found in the PRIDE Archive using the reference number PXD001370. A more comprehensive analysis of this data may be obtained from the article "Proteomic analysis and functional characterization of mouse brain mitochondria during aging reveal alterations in energy metabolism" in PROTEOMICS.

Original languageEnglish (US)
Pages (from-to)127-129
Number of pages3
JournalData in Brief
Volume4
DOIs
StatePublished - Sep 1 2015

Keywords

  • Aging
  • Mitochondria
  • Proteomics

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Data for mitochondrial proteomic alterations in the aging mouse brain'. Together they form a unique fingerprint.

  • Cite this