Data on macrophage mediated muscle transfection upon delivery of naked plasmid DNA with block copolymers

Vivek Mahajan, Zagit Gaymalov, Daria Alakhova, Richa Gupta, Irving H. Zucker, Alexander V. Kabanov

Research output: Contribution to journalArticle

Abstract

The data contains 14 figures supporting the research article "Horizontal gene transfer from macrophages to ischemic muscles upon delivery of naked DNA with Pluronic block copolymers" [1]. The data explains the surgical procedure and histological characterization of Murine Hind Limb Ischemia. The data also shows the kinetics of luciferase gene expression, spread of GFP expression through muscle and the colocalization of GFP with cellular markers in ischemic muscles injected with pDNA alone or pDNA/Pluronic. Finally the data shows the effect of Pluronic Block Copolymer to enhance total gene expression (cmv-promoter driven luciferase gene) in coculture of DNA transfected MØs with muscle cells.

Original languageEnglish (US)
Pages (from-to)1269-1282
Number of pages14
JournalData in Brief
Volume7
DOIs
StatePublished - Jun 1 2016

ASJC Scopus subject areas

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