Deciphering the mechanism of action of antitubercular compounds with metabolomics

Isin T. Sakallioglu, Raúl G. Barletta, Patrick H. Dussault, Robert Powers

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Tuberculosis (TB), one of the oldest and deadliest bacterial diseases, continues to cause serious global economic, health, and social problems. Current TB treatments are lengthy, expensive, and routinely ineffective against emerging drug resistant strains. Thus, there is an urgent need for the identification and development of novel TB drugs possessing comprehensive and specific mechanisms of action (MoAs). Metabolomics is a valuable approach to elucidating the MoA, toxicity, and potency of promising chemical leads, which is a critical step of the drug discovery process. Recent advances in metabolomics methodologies for deciphering MoAs include high-throughput screening techniques, the integration of multiple omics methods, mass spectrometry imaging, and software for automated analysis. This review describes recently introduced metabolomics methodologies and techniques for drug discovery, highlighting specific applications to the discovery of new antitubercular drugs and the elucidation of their MoAs.

Original languageEnglish (US)
Pages (from-to)4284-4299
Number of pages16
JournalComputational and Structural Biotechnology Journal
Volume19
DOIs
StatePublished - Jan 2021

Keywords

  • Antitubercular drugs
  • Drug discovery
  • Mechanisms of action
  • Metabolomics
  • Multi-drug resistant tuberculosis
  • Pharmacometabolomics
  • Tuberculosis

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Structural Biology
  • Biochemistry
  • Genetics
  • Computer Science Applications

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