Decoding Neuron Transcriptome by SAGE

Y. C. Kim, S. M. Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Serial analysis of gene expression (SAGE) is a widely used technique for gene expression studies and novel gene identification. SAGE has been extensively used to analyze gene expression in the human brain, including normal brain tissue and various types of brain tumor samples. This article summarizes the SAGE data collected from the human brain. Comparison with known human transcript sequences shows that most of the known human genes are expressed in the brain tissues. Mapping SAGE tags to the human genome sequences suggests the presence of substantial unknown transcribed regions in the human genome.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages357-363
Number of pages7
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Keywords

  • Annotation
  • Brain
  • Brain tumor
  • Gene expression
  • Genome
  • LongSAGE
  • Mapping
  • Normal tissue
  • Novel gene
  • SAGE
  • Tag
  • Transcriptome

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Kim, Y. C., & Wang, S. M. (2009). Decoding Neuron Transcriptome by SAGE. In Encyclopedia of Neuroscience (pp. 357-363). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.00879-2