Decreased Cold-Insoluble Globulin in Congenital Thrombocytopenia (Upshaw-Schulman Syndrome)

S. Rennard, S. Abe

Research output: Contribution to journalLetterpeer-review

36 Scopus citations


To the Editor: Cold-insoluble globulin is a plasma protein that coprecipitates with fibrinogen in the cold.1 A closely related protein, fibronectin, is a major constituent of the surface of fibroblasts and other cells and has been the subject of much recent interest.2 Cold-insoluble globulin binds to collagen3,4 and mediates the attachment and spreading of fibroblasts on collagen in vitro.5,6 Recently, Saba et al. have shown that it also mediates the uptake of gelatin-coated particles by the reticuloendothelial system and as such, appears to help the removal of circulating debris after tissue insult.7 Decreased levels of this protein have also followed. No extract is available for articles shorter than 400 words.

Original languageEnglish (US)
Pages (from-to)368
Number of pages1
JournalNew England Journal of Medicine
Issue number7
StatePublished - Feb 15 1979
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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