TY - JOUR
T1 - Decreased Cold-Insoluble Globulin in Congenital Thrombocytopenia (Upshaw-Schulman Syndrome)
AU - Rennard, S.
AU - Abe, S.
PY - 1979/2/15
Y1 - 1979/2/15
N2 - To the Editor: Cold-insoluble globulin is a plasma protein that coprecipitates with fibrinogen in the cold.1 A closely related protein, fibronectin, is a major constituent of the surface of fibroblasts and other cells and has been the subject of much recent interest.2 Cold-insoluble globulin binds to collagen3,4 and mediates the attachment and spreading of fibroblasts on collagen in vitro.5,6 Recently, Saba et al. have shown that it also mediates the uptake of gelatin-coated particles by the reticuloendothelial system and as such, appears to help the removal of circulating debris after tissue insult.7 Decreased levels of this protein have also followed. No extract is available for articles shorter than 400 words.
AB - To the Editor: Cold-insoluble globulin is a plasma protein that coprecipitates with fibrinogen in the cold.1 A closely related protein, fibronectin, is a major constituent of the surface of fibroblasts and other cells and has been the subject of much recent interest.2 Cold-insoluble globulin binds to collagen3,4 and mediates the attachment and spreading of fibroblasts on collagen in vitro.5,6 Recently, Saba et al. have shown that it also mediates the uptake of gelatin-coated particles by the reticuloendothelial system and as such, appears to help the removal of circulating debris after tissue insult.7 Decreased levels of this protein have also followed. No extract is available for articles shorter than 400 words.
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U2 - 10.1056/NEJM197902153000717
DO - 10.1056/NEJM197902153000717
M3 - Letter
C2 - 759902
AN - SCOPUS:0018790619
SN - 0028-4793
VL - 300
SP - 368
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 7
ER -