Decreased Levels of Helper T Cells in Pregnancy

Lorna Layward; Paul E.C. Brenchley; Beatrice M. Coupes; Christine M. Ellis; Richard S.H. Pumphrey; Norbert Gleicher; Israel Siegel; Vladimir Toder; Daniel F. Schafer; Anton Piskac; Kelley Kennedy; Joseph Eisenach; John Bennion; Greg Brown; Karen Dunker; Steven Freeman; Carolyn Haerr; Guillermo J. Ruiz-Argüelles; Philip R. Greipp; Vitaya Sridama; Sen Lian Yang; Atef Moawad; Leslie J. Degroot

doi:10.1056/NEJM198212163072516

Decreased Levels of Helper T Cells in Pregnancy

Lorna Layward, Paul E.C. Brenchley, Beatrice M. Coupes, Christine M. Ellis, Richard S.H. Pumphrey, Norbert Gleicher, Israel Siegel, Vladimir Toder, Daniel F. Schafer, Anton Piskac, Kelley Kennedy, Joseph Eisenach, John Bennion, Greg Brown, Karen Dunker, Steven Freeman, Carolyn Haerr, Guillermo J. Ruiz-Argüelles, Philip R. Greipp, Vitaya SridamaSen Lian Yang, Atef Moawad, Leslie J. Degroot

Research output: Contribution to journal › Letter › peer-review

13 Scopus citations

Abstract

To the Editor: In the paper by Sridama et al. (August 5 issue) data were presented showing decreased numbers of helper T cells in pregnancy.* We would like to present our observations of T-cell subpopulations in 20 women in the third trimester of pregnancy. Using Ortho monoclonal antibodies (OKT4 and OKT8) and a method similar to that used by Sridama et al., we found no important difference between pregnant women and controls in terms of the percentage of OKT4 (helper/inducer)-positive cells (Fig. 1). However, a marked reduction in OKT8 (suppressor/cytotoxic)-positive cells (P<0.05, by the two-tailed Student's t-test) was observed in.

Original language	English (US)
Pages (from-to)	1582-1583
Number of pages	2
Journal	New England Journal of Medicine
Volume	307
Issue number	25
DOIs	https://doi.org/10.1056/NEJM198212163072516
State	Published - Dec 16 1982
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1056/NEJM198212163072516

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Layward, L., Brenchley, P. E. C., Coupes, B. M., Ellis, C. M., Pumphrey, R. S. H., Gleicher, N., Siegel, I., Toder, V., Schafer, D. F., Piskac, A., Kennedy, K., Eisenach, J., Bennion, J., Brown, G., Dunker, K., Freeman, S., Haerr, C., Ruiz-Argüelles, G. J., Greipp, P. R., ... Degroot, L. J. (1982). Decreased Levels of Helper T Cells in Pregnancy. New England Journal of Medicine, 307(25), 1582-1583. https://doi.org/10.1056/NEJM198212163072516

Layward, L, Brenchley, PEC, Coupes, BM, Ellis, CM, Pumphrey, RSH, Gleicher, N, Siegel, I, Toder, V, Schafer, DF, Piskac, A, Kennedy, K, Eisenach, J, Bennion, J, Brown, G, Dunker, K, Freeman, S, Haerr, C, Ruiz-Argüelles, GJ, Greipp, PR, Sridama, V, Yang, SL, Moawad, A & Degroot, LJ 1982, 'Decreased Levels of Helper T Cells in Pregnancy', New England Journal of Medicine, vol. 307, no. 25, pp. 1582-1583. https://doi.org/10.1056/NEJM198212163072516

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title = "Decreased Levels of Helper T Cells in Pregnancy",

abstract = "To the Editor: In the paper by Sridama et al. (August 5 issue) data were presented showing decreased numbers of helper T cells in pregnancy.* We would like to present our observations of T-cell subpopulations in 20 women in the third trimester of pregnancy. Using Ortho monoclonal antibodies (OKT4 and OKT8) and a method similar to that used by Sridama et al., we found no important difference between pregnant women and controls in terms of the percentage of OKT4 (helper/inducer)-positive cells (Fig. 1). However, a marked reduction in OKT8 (suppressor/cytotoxic)-positive cells (P<0.05, by the two-tailed Student's t-test) was observed in.",

author = "Lorna Layward and Brenchley, {Paul E.C.} and Coupes, {Beatrice M.} and Ellis, {Christine M.} and Pumphrey, {Richard S.H.} and Norbert Gleicher and Israel Siegel and Vladimir Toder and Schafer, {Daniel F.} and Anton Piskac and Kelley Kennedy and Joseph Eisenach and John Bennion and Greg Brown and Karen Dunker and Steven Freeman and Carolyn Haerr and Ruiz-Arg{\"u}elles, {Guillermo J.} and Greipp, {Philip R.} and Vitaya Sridama and Yang, {Sen Lian} and Atef Moawad and Degroot, {Leslie J.}",

year = "1982",

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doi = "10.1056/NEJM198212163072516",

language = "English (US)",

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AU - Layward, Lorna

AU - Brenchley, Paul E.C.

AU - Coupes, Beatrice M.

AU - Ellis, Christine M.

AU - Pumphrey, Richard S.H.

AU - Gleicher, Norbert

AU - Siegel, Israel

AU - Toder, Vladimir

AU - Schafer, Daniel F.

AU - Piskac, Anton

AU - Kennedy, Kelley

AU - Eisenach, Joseph

AU - Bennion, John

AU - Brown, Greg

AU - Dunker, Karen

AU - Freeman, Steven

AU - Haerr, Carolyn

AU - Ruiz-Argüelles, Guillermo J.

AU - Greipp, Philip R.

AU - Sridama, Vitaya

AU - Yang, Sen Lian

AU - Moawad, Atef

AU - Degroot, Leslie J.

PY - 1982/12/16

Y1 - 1982/12/16

N2 - To the Editor: In the paper by Sridama et al. (August 5 issue) data were presented showing decreased numbers of helper T cells in pregnancy.* We would like to present our observations of T-cell subpopulations in 20 women in the third trimester of pregnancy. Using Ortho monoclonal antibodies (OKT4 and OKT8) and a method similar to that used by Sridama et al., we found no important difference between pregnant women and controls in terms of the percentage of OKT4 (helper/inducer)-positive cells (Fig. 1). However, a marked reduction in OKT8 (suppressor/cytotoxic)-positive cells (P<0.05, by the two-tailed Student's t-test) was observed in.

AB - To the Editor: In the paper by Sridama et al. (August 5 issue) data were presented showing decreased numbers of helper T cells in pregnancy.* We would like to present our observations of T-cell subpopulations in 20 women in the third trimester of pregnancy. Using Ortho monoclonal antibodies (OKT4 and OKT8) and a method similar to that used by Sridama et al., we found no important difference between pregnant women and controls in terms of the percentage of OKT4 (helper/inducer)-positive cells (Fig. 1). However, a marked reduction in OKT8 (suppressor/cytotoxic)-positive cells (P<0.05, by the two-tailed Student's t-test) was observed in.

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JO - New England Journal of Medicine

JF - New England Journal of Medicine

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Decreased Levels of Helper T Cells in Pregnancy

Abstract

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