Decreased Levels of Helper T Cells in Pregnancy

Lorna Layward, Paul E.C. Brenchley, Beatrice M. Coupes, Christine M. Ellis, Richard S.H. Pumphrey, Norbert Gleicher, Israel Siegel, Vladimir Toder, Daniel F. Schafer, Anton Piskac, Kelley Kennedy, Joseph Eisenach, John Bennion, Greg Brown, Karen Dunker, Steven Freeman, Carolyn Haerr, Guillermo J. Ruiz-Argüelles, Philip R. Greipp, Vitaya SridamaSen Lian Yang, Atef Moawad, Leslie J. Degroot

Research output: Contribution to journalLetterpeer-review

13 Scopus citations


To the Editor: In the paper by Sridama et al. (August 5 issue) data were presented showing decreased numbers of helper T cells in pregnancy.* We would like to present our observations of T-cell subpopulations in 20 women in the third trimester of pregnancy. Using Ortho monoclonal antibodies (OKT4 and OKT8) and a method similar to that used by Sridama et al., we found no important difference between pregnant women and controls in terms of the percentage of OKT4 (helper/inducer)-positive cells (Fig. 1). However, a marked reduction in OKT8 (suppressor/cytotoxic)-positive cells (P<0.05, by the two-tailed Student's t-test) was observed in.

Original languageEnglish (US)
Pages (from-to)1582-1583
Number of pages2
JournalNew England Journal of Medicine
Issue number25
StatePublished - Dec 16 1982
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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