Deep brain stimulation in Parkinson disease: A metaanalysis of patient outcomes

Frances Weaver, Kenneth Follett, Kwan Hur, Dolores Ippolito, Matthew Stern

Research output: Contribution to journalArticlepeer-review

142 Scopus citations


Object. Deep brain stimulation (DBS) to treat advanced Parkinson disease (PD) has been focused on one of two anatomical targets: the subthalamic nucleus (STN) and the globus pallidus internus (GPI). Authors of more than 65 articles have reported on bilateral DBS outcomes. With one exception, these studies involved pre- and postintervention comparisons of a single target. Despite the paucity of data directly comparing STN and GPI DBS, many clinicians already consider the STN to be the preferred target site. In this study the authors conducted a metaanalysis of the existing literature on patient outcomes following DBS of the STN and the GPI. Methods. This metaanalysis includes 31 STN and 14 GPI studies. Motor function improved significantly following stimulation (54% in patients whose STN was targeted and 40% in those whose GPI was stimulated), with effect sizes (ESs) of 2.59 and 2.04, respectively. After controlling for participant and study characteristics, patients who had undergone either STN or GPI DBS experienced comparable improved motor function following surgery (p = 0.094). The performance of activities of daily living improved significantly in patients with either target (40%). Medication requirements were significantly reduced following stimulation of the STN (ES = 1.51) but did not change when the GPI was stimulated (ES = 20.02). Conclusions. In this analysis the authors highlight the need for uniform, detailed reporting of comprehensive motor and nonmotor DBS outcomes at multiple time points and for a randomized trial of bilateral STN and GPI DBS.

Original languageEnglish (US)
Pages (from-to)956-967
Number of pages12
JournalJournal of neurosurgery
Issue number6
StatePublished - Dec 2005
Externally publishedYes


  • Deep brain stimulation
  • Globus pallidus internus
  • Parkinson disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


Dive into the research topics of 'Deep brain stimulation in Parkinson disease: A metaanalysis of patient outcomes'. Together they form a unique fingerprint.

Cite this