Deep Sweet Syndrome Secondary to Pegfilgrastim

Dillon Clarey, Dominick DiMaio, Ryan Trowbridge

Research output: Contribution to journalArticlepeer-review


Sweet syndrome, or acute febrile neutrophilic dermatosis, is a skin condition consisting of erythematous papules and plaques in association with fever, neutrophilia, and a neutrophilic infiltrate that typically involves the papillary dermis. Although development is most commonly idiopathic, medications are also frequently associated with the eruption, notably, the granulocyte colony-stimulating factor (G-CSF), filgrastim. Pegylated G-CSF, despite similar activity, is not commonly reported, with only four published cases. We present a case of drug-induced sweet syndrome with unique histologic features (deep inflammatory infiltrate) in association with the usage of pegfilgrastim in the treatment of invasive ductal carcinoma of the breast. J Drugs Dermatol. 2022;21(4):422-424. doi:10.36849/JDD.4794.

Original languageEnglish (US)
Pages (from-to)422-424
Number of pages3
JournalJournal of drugs in dermatology : JDD
Issue number4
StatePublished - Apr 1 2022

ASJC Scopus subject areas

  • Medicine(all)


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