Defective actin organization in cultured skin fibroblasts from individuals with inherited colon adenocarcinoma is not restored by addition of fibronectin

Levy Kopelovich, Clifford Murray, Hynda K. Kleinman, George R. Martin, Yuh Fukuda, Stephen I. Rennard

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Cultured skin fibroblasts from patients with hereditary adenomatosis of the colon and rectum (ACR) have a disorganized cytoskeleton. Since fibronectin has been found to restore normal cytoskeletal and cellular morphology to transformed cells, we investigated the fibronectin pattern in ACR cells. We found that although both fibronectin synthesis and binding to the cell surface were apparently normal, addition of fibronectin did not restore a normal distribution of actin cables to ACR cells. The data suggest that coupling of cell surface-bound fibronectin to the cytoskeleton might be constitutively defective in ACR cells.

Original languageEnglish (US)
Pages (from-to)314-321
Number of pages8
JournalPathobiology
Volume53
Issue number6
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Keywords

  • Cancer predisposition
  • Constitutive
  • Cultured human fibroblasts
  • Defective actin organization
  • Fibronectin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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