TY - JOUR
T1 - Defining larger roles for "tiny" RNA molecules
T2 - Role of miRNAs in neurodegeneration research
AU - Yelamanchili, Sowmya V.
AU - Fox, Howard S.
N1 - Funding Information:
Acknowledgments This is manuscript #05 from the UNMC Center for Integrative and Translational Neuroscience. The work of the authors is supported by NIH grants P30 MH062261, R01 MH073490, and P01 DA026146.
PY - 2010/3
Y1 - 2010/3
N2 - Many facets of transcriptional and translational regulation contribute to the proper functioning of the nervous system. Dysfunctional control of mRNA and protein expression can lead to neurodegenerative conditions. Recently, a new regulatory control element-small noncoding RNAs-has been found to play a significant role in many physiologic systems. Here, we review the microRNA (miRNA) field as it pertains to discovery-based and mechanistic studies on the brain and specifically in neurodegenerative disorders. Understanding the role of miRNAs in the brain will aid to open new avenues to the field of neuroscience and, importantly, neurodegenerative disease research.
AB - Many facets of transcriptional and translational regulation contribute to the proper functioning of the nervous system. Dysfunctional control of mRNA and protein expression can lead to neurodegenerative conditions. Recently, a new regulatory control element-small noncoding RNAs-has been found to play a significant role in many physiologic systems. Here, we review the microRNA (miRNA) field as it pertains to discovery-based and mechanistic studies on the brain and specifically in neurodegenerative disorders. Understanding the role of miRNAs in the brain will aid to open new avenues to the field of neuroscience and, importantly, neurodegenerative disease research.
KW - Gene array
KW - HIV
KW - MRNA
KW - MicroRNA
KW - Neurodegeneration
KW - Neuron
KW - Transcriptional regulation
KW - Translational regulation
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U2 - 10.1007/s11481-009-9172-4
DO - 10.1007/s11481-009-9172-4
M3 - Review article
C2 - 19757077
AN - SCOPUS:77249143447
SN - 1557-1890
VL - 5
SP - 63
EP - 69
JO - Journal of Neuroimmune Pharmacology
JF - Journal of Neuroimmune Pharmacology
IS - 1
ER -