Defining larger roles for "tiny" RNA molecules: Role of miRNAs in neurodegeneration research

Sowmya V. Yelamanchili; Howard S. Fox

doi:10.1007/s11481-009-9172-4

Defining larger roles for "tiny" RNA molecules: Role of miRNAs in neurodegeneration research

Sowmya V. Yelamanchili, Howard S. Fox

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Many facets of transcriptional and translational regulation contribute to the proper functioning of the nervous system. Dysfunctional control of mRNA and protein expression can lead to neurodegenerative conditions. Recently, a new regulatory control element-small noncoding RNAs-has been found to play a significant role in many physiologic systems. Here, we review the microRNA (miRNA) field as it pertains to discovery-based and mechanistic studies on the brain and specifically in neurodegenerative disorders. Understanding the role of miRNAs in the brain will aid to open new avenues to the field of neuroscience and, importantly, neurodegenerative disease research.

Original language	English (US)
Pages (from-to)	63-69
Number of pages	7
Journal	Journal of Neuroimmune Pharmacology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1007/s11481-009-9172-4
State	Published - Mar 2010

Keywords

Gene array
HIV
MRNA
MicroRNA
Neurodegeneration
Neuron
Transcriptional regulation
Translational regulation

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Immunology and Allergy
Immunology
Pharmacology

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10.1007/s11481-009-9172-4

Cite this

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abstract = "Many facets of transcriptional and translational regulation contribute to the proper functioning of the nervous system. Dysfunctional control of mRNA and protein expression can lead to neurodegenerative conditions. Recently, a new regulatory control element-small noncoding RNAs-has been found to play a significant role in many physiologic systems. Here, we review the microRNA (miRNA) field as it pertains to discovery-based and mechanistic studies on the brain and specifically in neurodegenerative disorders. Understanding the role of miRNAs in the brain will aid to open new avenues to the field of neuroscience and, importantly, neurodegenerative disease research.",

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note = "Funding Information: Acknowledgments This is manuscript #05 from the UNMC Center for Integrative and Translational Neuroscience. The work of the authors is supported by NIH grants P30 MH062261, R01 MH073490, and P01 DA026146.",

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Defining larger roles for "tiny" RNA molecules: Role of miRNAs in neurodegeneration research

Abstract

Keywords

ASJC Scopus subject areas

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