Degradation modeling of poly-L-lactide acid (PLLA) bioresorbable vascular scaffold within a coronary artery

Shengmao Lin, Pengfei Dong, Changchun Zhou, Luis Augusto P. Dallan, Vladislav N. Zimin, Gabriel T.R. Pereira, Juhwan Lee, Yazan Gharaibeh, David L. Wilson, Hiram G. Bezerra, Linxia Gu

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

In this work, a strain-based degradation model was implemented and validated to better understand the dynamic interactions between the bioresorbable vascular scaffold (BVS) and the artery during the degradation process. Integrating the strain-modulated degradation equation into commercial finite element codes allows a better control and visualization of local mechanical parameters. Both strut thinning and discontinuity of the stent struts within an artery were captured and visualized. The predicted results in terms of mass loss and fracture locations were validated by the documented experimental observations. In addition, results suggested that the heterogeneous degradation of the stent depends on its strain distribution following deployment. Degradation is faster at the locations with higher strains and resulted in the strut thinning and discontinuity, which contributes to the continuous mass loss, and the reduced contact force between the BVS and artery. A nonlinear relationship between the maximum principal strain of the stent and the fracture time was obtained, which could be transformed to predict the degradation process of the BVS in different mechanical environments. The developed computational model provided more insights into the degradation process, which could complement the discrete experimental data for improving the design and clinical management of the BVS.

Original languageEnglish (US)
Pages (from-to)1217-1226
Number of pages10
JournalNanotechnology Reviews
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2020
Externally publishedYes

Keywords

  • bioresorbable vascular scaffold
  • coronary artery
  • degradation
  • finite element method
  • percutaneous coronary intervention
  • poly- l -lactide acid
  • stent

ASJC Scopus subject areas

  • Biotechnology
  • Medicine (miscellaneous)
  • Materials Science (miscellaneous)
  • Energy Engineering and Power Technology
  • Engineering (miscellaneous)
  • Process Chemistry and Technology

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