Deletion of cell division cycle 2-like 1 gene locus on 1p36 in non- Hodgkin lymphoma

Bhavana J. Dave, Diane L. Pickering, Michelle M. Hess, Dennis D. Weisenburger, James O. Armitage, Warren G. Sanger

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Our laboratories have documented a significantly high occurrence of chromosome 1p36 rearrangements in non-Hodgkin lymph area (NHL). The cell division cycle 2-like 1(CDC2L1) (also known as TP58 or PITSLRE) gene, a protein kinase implicated in apoptotic signaling, is located at the very distal region of chromosome 1p36 and is likely to be disrupted by structural rearrangements involving 1p36. To determine the molecular consequences of the recurrent involvement of the 1p36 region, we examined metephases containing 1p36 abnormalities from 31 specimens derived from 26 patients for the possible deletion of CDC2L1 by fluorescence in situ hybridization (FISH) using the TP58(clk-1) DNA probe. Twenty-three cases exhibited the loss of CDC2L1 from the abnormal chromosome 1. In 2 of 26 cases, the gene locus was translocated to the partner chromosome, and in four specimens, all derived from one case, CDC2L1 was not deleted. This pilot investigation suggests that 1p36 rearrangements, and consequently the loss of the CDC2L1 gene locus, is important in NHL. This work also opens avenues for further molecular studies and prognostic correlations.

Original languageEnglish (US)
Pages (from-to)120-126
Number of pages7
JournalCancer genetics and cytogenetics
Volume108
Issue number2
DOIs
StatePublished - Jan 15 1999

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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