Delivery and targeting of oligonucleotides and siRNA

Ningning Yang, Ram I. Mahato

Research output: Chapter in Book/Report/Conference proceedingChapter


Oligodeoxynucleotides (ODNs) are increasingly being recognized as potential therapeutic agents to modulate aberrant gene expression for treating various diseases, including cancers1-3 and viral infections.4,5 Concerted efforts have made signicant progress in turning these nucleic acids into therapeutics. Apart from immune-stimulation and enzymatic cleavage, the most important feature of ODNs is their ability to block mRNA function by sequence-specic hybridization with target mRNA.6 Theoretically, the antisense strategy can be used to target any gene in the body, which allows these nucleic acids to achieve broader therapeutic potential than small molecules.

Original languageEnglish (US)
Title of host publicationTargeted Delivery of Small and Macromolecular Drugs
PublisherCRC Press
Number of pages24
ISBN (Electronic)9781420087734
ISBN (Print)9781420087727
StatePublished - Jan 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)


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