Dementia and the ncurovirulence of HIV-1

Paul Shapshak, Robert K. Fujimura, Ashok Srivastava, Karl Goodkin

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Infection with hitman immunodeficiency virus type 1 (HIV-1) leads rapidly to infection of the brain and subsequent neuropsychological impairment, including subclinical impairment, minor cognitive-motor disorder, and HIV1-associated dementia (HAD). This article reviews HAD and the factors involved in its pathogenesis; the effectiveness of antiretroviral therapy; the prevalence of HIV-1. and subtypes; and the role ofchemokines and cytokines as the capstones associated ivith neuropathology due to inflammation.

Original languageEnglish (US)
Pages (from-to)31-42
Number of pages12
JournalCNS Spectrums
Issue number4
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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