Dendritic Peptide Release Mediates Interpopulation Crosstalk between Neurosecretory and Preautonomic Networks

Sook Jin Son, Jessica A. Filosa, Evgeniy S. Potapenko, Vinicia C. Biancardi, Hong Zheng, Kaushik P. Patel, Vicky A. Tobin, Mike Ludwig, Javier E. Stern

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

Although communication between neurons is considered a function of the synapse, neurons also release neurotransmitter from their dendrites. We found that dendritic transmitter release coordinates activity across distinct neuronal populations to generate integrative homeostatic responses. We show that activity-dependent vasopressin release from hypothalamic neuroendocrine neurons in the paraventricular nucleus stimulates neighboring (~100μm soma-to-soma) presympathetic neurons, resulting in a sympathoexcitatory population response. This interpopulation crosstalk was engaged by an NMDA-mediated increase in dendritic Ca2+, influenced by vasopressin@s ability to diffuse in the extracellular space, and involved activation of CAN channels at the target neurons. Furthermore, we demonstrate that this interpopulation crosstalk plays a pivotal role in the generation of a systemic, polymodal neurohumoral response to a hyperosmotic challenge. Because dendritic release is emerging as a widespread process, our results suggest that a similar mechanism could mediate interpopulation crosstalk in other brain systems, particularly those involved in generating complex behaviors

Original languageEnglish (US)
Pages (from-to)1036-1049
Number of pages14
JournalNeuron
Volume78
Issue number6
DOIs
StatePublished - Jun 19 2013

ASJC Scopus subject areas

  • Neuroscience(all)

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    Son, S. J., Filosa, J. A., Potapenko, E. S., Biancardi, V. C., Zheng, H., Patel, K. P., Tobin, V. A., Ludwig, M., & Stern, J. E. (2013). Dendritic Peptide Release Mediates Interpopulation Crosstalk between Neurosecretory and Preautonomic Networks. Neuron, 78(6), 1036-1049. https://doi.org/10.1016/j.neuron.2013.04.025