Dendritic spine morphogenesis and plasticity

Jocelyn Lippman, Anna Dunaevsky

Research output: Contribution to journalReview article

108 Scopus citations

Abstract

Dendritic spines are small protrusions off the dendrite that receive excitatory synaptic input. Spines vary in size, likely correlating with the strength of the synapses they form. In the developing brain, spines show highly dynamic behavior thought to facilitate the formation of new synaptic contacts. Recent studies have illuminated the numerous molecules regulating spine development, many of which converge on the regulation of actin filaments. In addition, interactions with glial cells are emerging as important regulators of spine morphology. In many cases, spine morphogenesis, plasticity, and maintenance also depend on synaptic activity, as shown by recent studies demonstrating changes in spine dynamics and maintenance with altered sensory experience.

Original languageEnglish (US)
Pages (from-to)47-57
Number of pages11
JournalJournal of Neurobiology
Volume64
Issue number1
DOIs
StatePublished - Jul 2005

Keywords

  • Multi-photon microscopy
  • Synapse
  • Synaptogenesis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

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