Depressor effect of closed-loop chip system in spontaneously hypertensive rats

Xing Ya Gao, Xing Lin Huang, Han Jun Wang, Li Min Zhou, Yao Xu, Wei Wang, Guo Qing Zhu

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We previously reported that a closed-loop chip system was designed to decrease arterial pressure in normal rabbits and rats. In the present study, the depressor effects of the chip system were investigated in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). The arterial pressure was recorded, sampled, operated and processed in the chip system. The chip system instantaneously controlled arterial pressure by stimulating the left aortic depressor nerve according to the feedback signals of arterial pressure. The closed-loop chip system effectively decreased mean arterial pressure (MAP) and heart rate (HR) in both SHR and WKY rats. It decreased the duration and the maximal MAP level of the pressor response evoked by either intravenous injection of phenylephrine or cutaneous nociceptive stimulation in SHR, but had no significant effect on the magnitude of the increase in MAP. Furthermore, the chip system significantly increased the baroreflex gain in SHR, but not in normal WKY rats. These results suggest that the closed-loop chip system effectively decreases the arterial pressure and increases baroreflex gain in SHR. The chip system does not abolish the arterial pressure responses to accidental pressor events, but decreases the duration and the maximal MAP level of the pressor responses.

Original languageEnglish (US)
Pages (from-to)84-91
Number of pages8
JournalAutonomic Neuroscience: Basic and Clinical
Issue number1-2
StatePublished - Dec 30 2007
Externally publishedYes


  • Baroreflex
  • Blood pressure
  • Chip
  • Hypertension

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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