Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters

Patrick F. Kiser; Allen A. Thomas; Gary M. Eichenbaum; David Needham; Intae Kim

Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters

Patrick F. Kiser, Allen A. Thomas, Gary M. Eichenbaum, David Needham, Intae Kim

Research output: Contribution to journal › Conference article › peer-review

Abstract

The synthesis and testing of the first symmetrical based on vinylic oligomers of α-hydroxy acids are described. Biodegradable gel networks with chemically defined crosslinks were made and studied and were shown to degrade at a defined rate in response to the environment in which they are bathed. The degradation rate of gels composed of the crosslinkers conform to the known order of importance of steric and electronic effects in ester hydrolysis, as well as the concentration of acid or base. The advantages of the crosslinkers over related technologies are discussed. The oligomers were characterized by nuclear magnetic resonance (NMR) spectroscopy.

Original language	English (US)
Pages (from-to)	712-713
Number of pages	2
Journal	American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume	41
Issue number	1
State	Published - Mar 2000
Externally published	Yes
Event	The San Francisco Meeting - San Francisco, CA, USA Duration: Mar 26 2000 → Mar 31 2000

ASJC Scopus subject areas

Polymers and Plastics

Cite this

Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters. / Kiser, Patrick F.; Thomas, Allen A.; Eichenbaum, Gary M. et al.
In: American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, Vol. 41, No. 1, 03.2000, p. 712-713.

Research output: Contribution to journal › Conference article › peer-review

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abstract = "The synthesis and testing of the first symmetrical based on vinylic oligomers of α-hydroxy acids are described. Biodegradable gel networks with chemically defined crosslinks were made and studied and were shown to degrade at a defined rate in response to the environment in which they are bathed. The degradation rate of gels composed of the crosslinkers conform to the known order of importance of steric and electronic effects in ester hydrolysis, as well as the concentration of acid or base. The advantages of the crosslinkers over related technologies are discussed. The oligomers were characterized by nuclear magnetic resonance (NMR) spectroscopy.",

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pages = "712--713",

journal = "American Chemical Society, Polymer Preprints, Division of Polymer Chemistry",

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T1 - Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters

AU - Kiser, Patrick F.

AU - Thomas, Allen A.

AU - Eichenbaum, Gary M.

AU - Needham, David

AU - Kim, Intae

PY - 2000/3

Y1 - 2000/3

N2 - The synthesis and testing of the first symmetrical based on vinylic oligomers of α-hydroxy acids are described. Biodegradable gel networks with chemically defined crosslinks were made and studied and were shown to degrade at a defined rate in response to the environment in which they are bathed. The degradation rate of gels composed of the crosslinkers conform to the known order of importance of steric and electronic effects in ester hydrolysis, as well as the concentration of acid or base. The advantages of the crosslinkers over related technologies are discussed. The oligomers were characterized by nuclear magnetic resonance (NMR) spectroscopy.

AB - The synthesis and testing of the first symmetrical based on vinylic oligomers of α-hydroxy acids are described. Biodegradable gel networks with chemically defined crosslinks were made and studied and were shown to degrade at a defined rate in response to the environment in which they are bathed. The degradation rate of gels composed of the crosslinkers conform to the known order of importance of steric and electronic effects in ester hydrolysis, as well as the concentration of acid or base. The advantages of the crosslinkers over related technologies are discussed. The oligomers were characterized by nuclear magnetic resonance (NMR) spectroscopy.

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UR - http://www.scopus.com/inward/citedby.url?scp=0033741021&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0033741021

SN - 0032-3934

VL - 41

SP - 712

EP - 713

JO - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

JF - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

IS - 1

T2 - The San Francisco Meeting

Y2 - 26 March 2000 through 31 March 2000

ER -

Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters

Abstract

ASJC Scopus subject areas

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