Design and synthesis of an activity-based probe template for protein kinases

Santosh Keshipeddy; Shi Yu; Nathan Hnatiuk; Martha Morton; Xudong Yao; Amy R. Howell

doi:10.1055/s-0029-1218543

Design and synthesis of an activity-based probe template for protein kinases

Santosh Keshipeddy, Shi Yu, Nathan Hnatiuk, Martha Morton, Xudong Yao, Amy R. Howell

Research output: Contribution to journal › Article › peer-review

Abstract

A potential activity-based probe for protein kinases was designed around mechanism-based inhibitors of insulin receptor kinase. The probe was synthesized by a chemoselective conjugate addition of ATPγS to an epoxyenone.

Original language	English (US)
Article number	D23809ST
Pages (from-to)	521-524
Number of pages	4
Journal	Synlett
Issue number	4
DOIs	https://doi.org/10.1055/s-0029-1218543
State	Published - 2010
Externally published	Yes

Keywords

Activity-based probes
Addition reactions
Enones
Epoxides
Regioselectivity

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-0029-1218543

Cite this

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title = "Design and synthesis of an activity-based probe template for protein kinases",

abstract = "A potential activity-based probe for protein kinases was designed around mechanism-based inhibitors of insulin receptor kinase. The probe was synthesized by a chemoselective conjugate addition of ATPγS to an epoxyenone.",

keywords = "Activity-based probes, Addition reactions, Enones, Epoxides, Regioselectivity",

author = "Santosh Keshipeddy and Shi Yu and Nathan Hnatiuk and Martha Morton and Xudong Yao and Howell, {Amy R.}",

year = "2010",

doi = "10.1055/s-0029-1218543",

language = "English (US)",

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AU - Keshipeddy, Santosh

AU - Yu, Shi

AU - Hnatiuk, Nathan

AU - Morton, Martha

AU - Yao, Xudong

AU - Howell, Amy R.

PY - 2010

Y1 - 2010

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KW - Activity-based probes

KW - Addition reactions

KW - Enones

KW - Epoxides

KW - Regioselectivity

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M3 - Article

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JO - Synlett

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M1 - D23809ST

ER -

Design and synthesis of an activity-based probe template for protein kinases

Abstract

Keywords

ASJC Scopus subject areas

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