Design and synthesis of an activity-based probe template for protein kinases

Santosh Keshipeddy, Shi Yu, Nathan Hnatiuk, Martha Morton, Xudong Yao, Amy R. Howell

Research output: Contribution to journalArticlepeer-review

Abstract

A potential activity-based probe for protein kinases was designed around mechanism-based inhibitors of insulin receptor kinase. The probe was synthesized by a chemoselective conjugate addition of ATPγS to an epoxyenone.

Original languageEnglish (US)
Article numberD23809ST
Pages (from-to)521-524
Number of pages4
JournalSynlett
Issue number4
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Activity-based probes
  • Addition reactions
  • Enones
  • Epoxides
  • Regioselectivity

ASJC Scopus subject areas

  • Organic Chemistry

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