TY - GEN
T1 - Design of a soft, self-uncoiling stent for extended retention of drug delivery in the small intestine
AU - Sarker, Sunandita
AU - Jones, Ryan
AU - Chow, Gabriel
AU - Terry, Benjamin
N1 - Publisher Copyright:
© 2021 by ASME.
PY - 2021
Y1 - 2021
N2 - Despite being the preferred route of drug administration, the oral formulation of biological drugs is limited due to its intrinsic instability, low permeability, and physical, chemical and immunological barriers. Various innovative swallowable technologies such as drug-loaded, dissolvable microneedles, mucoadhesive patches, and various microdevices present unique drug-carrying capabilities. The current work presents a novel soft stent platform that can facilitate contact between the small intestine tissue and drug carriers to enhance drug absorption and increase residence time. This study aims to prove the concept of this novel platform and determine if the soft stent will retain orally to the ileocecal valve longer than a capsule-shaped bolus. Benchtop studies on an intestinal simulator showed successful retention of the soft stent compared to a control capsule. In vivo studies in pig models also showed that the soft stent was retained longer than the control capsule. Overall, this study shows promise that this novel platform could be used for oral drug delivery of biologics.
AB - Despite being the preferred route of drug administration, the oral formulation of biological drugs is limited due to its intrinsic instability, low permeability, and physical, chemical and immunological barriers. Various innovative swallowable technologies such as drug-loaded, dissolvable microneedles, mucoadhesive patches, and various microdevices present unique drug-carrying capabilities. The current work presents a novel soft stent platform that can facilitate contact between the small intestine tissue and drug carriers to enhance drug absorption and increase residence time. This study aims to prove the concept of this novel platform and determine if the soft stent will retain orally to the ileocecal valve longer than a capsule-shaped bolus. Benchtop studies on an intestinal simulator showed successful retention of the soft stent compared to a control capsule. In vivo studies in pig models also showed that the soft stent was retained longer than the control capsule. Overall, this study shows promise that this novel platform could be used for oral drug delivery of biologics.
KW - Biological drug
KW - Microneedle
KW - Oral drug delivery
KW - Tissue contact
UR - http://www.scopus.com/inward/record.url?scp=85107184128&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85107184128&partnerID=8YFLogxK
U2 - 10.1115/DMD2021-1063
DO - 10.1115/DMD2021-1063
M3 - Conference contribution
AN - SCOPUS:85107184128
T3 - Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021
BT - Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021
PB - American Society of Mechanical Engineers
T2 - 2021 Design of Medical Devices Conference, DMD 2021
Y2 - 12 April 2021 through 15 April 2021
ER -