Design of the subpopulations and intermediate outcomes in copd study (SPIROMICS)

David Couper, Lisa M. LaVange, Mei Lan Han, R. Graham Barr, Eugene Bleecker, Eric A. Hoffman, Richard Kanner, Eric Kleerup, Fernando J. Martinez, Prescott G. Woodruff, Stephen Rennard

Research output: Contribution to journalArticle

150 Scopus citations

Abstract

Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) is a multicentre observational study of chronic obstructive pulmonary disease (COPD) designed to guide future development of therapies for COPD by providing robust criteria for subclassifying COPD participants into groups most likely to benefit from a given therapy during a clinical trial, and identifying biomarkers/phenotypes that can be used as intermediate outcomes to reliably predict clinical benefit during therapeutic trials. The goal is to enrol 3200 participants in four strata. Participants undergo a baseline visit and three annual follow-up examinations, with quarterly telephone calls. Adjudication of exacerbations and mortality will be undertaken.

Original languageEnglish (US)
Pages (from-to)491-494
Number of pages4
JournalThorax
Volume69
Issue number5
DOIs
StatePublished - May 2014

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Couper, D., LaVange, L. M., Han, M. L., Barr, R. G., Bleecker, E., Hoffman, E. A., Kanner, R., Kleerup, E., Martinez, F. J., Woodruff, P. G., & Rennard, S. (2014). Design of the subpopulations and intermediate outcomes in copd study (SPIROMICS). Thorax, 69(5), 491-494. https://doi.org/10.1136/thoraxjnl-2013-203897