Design of triple helix forming C-glycoside molecules

Jian Sen Li, Yun Hua Fan, Yi Zhang, Luis A. Marky, Barry Gold

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

The modeling, synthesis, and characterization of oligomers containing 2-aminoquinazolin-5-yl 2′-deoxynucleotide residues are reported. The 2-aminoquinazoline residues sequence specifically bind via Hoogsteen base pairing as a third strand in the center of the major groove at T:A base pair Watson-Crick duplex sequences. Evidence for the formation of a sequence specific three-stranded structure is based on thermal denaturation UV-vis and fluorescence studies. The novel 2-aminoquinazoline C-nucleotide is a component of a system designed to overcome the homopurine requirement for triple helix structures.

Original languageEnglish (US)
Pages (from-to)2084-2093
Number of pages10
JournalJournal of the American Chemical Society
Volume125
Issue number8
DOIs
StatePublished - Feb 26 2003

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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