Desmoplasia in pancreatic ductal adenocarcinoma: Insight into pathological function and therapeutic potential

Andrew Cannon, Christopher Thompson, Bradley R. Hall, Maneesh Jain, Sushil Kumar, Surinder K. Batra

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Extensive desmoplasia is a prominent feature of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Initially, studies demonstrated that desmoplasia promotes proliferation, invasion and chemoresistance in PDAC cells. While these findings suggested the therapeutic potential of targeting desmoplasia in PDAC, more recent studies utilizing genetically-engineered mouse models of PDAC, which lack key components of desmoplasia, demonstrated accelerated progression of PDAC. This contrast calls into question the paradigm that desmoplasia unilaterally promotes PDAC progression and the premise of desmoplasia-targeted therapy. This review briefly examines the major reports of the tumor-promoting and-restraining roles of desmoplasia in PDAC with commentary on the gaps in our current understanding of desmoplasia in PDAC. Additionally, we discuss the studies demonstrating the heterogeneous and multifaceted nature of desmoplasia in PDAC and advocate for future areas of research to thoroughly address the various facets of desmoplasia in PDAC, reconcile seemingly contradictory reports of the role of desmoplasia in PDAC progression, and discover aspects of desmoplasia that are therapeutically actionable.

Original languageEnglish (US)
Pages (from-to)78-86
Number of pages9
JournalGenes and Cancer
Volume9
Issue number3-4
DOIs
StatePublished - Mar 2018

Keywords

  • Cancer-associated fibroblast
  • Desmoplasia
  • Extracellular matrix
  • Pancreatic ductal adenocarcinoma
  • SHH

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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