Desmoplastic fibroma arising in fibrous dysplasia. Chromosomal analysis and review of the literature

J. A. Bridge, H. Rosenthal, W. G. Sanger, J. R. Neff

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

A desmoplastic fibroma of bone arose in the fibula of a 17-year-old boy with fibrous dysplasia. This may be the second case of this rare histopathologic association reported in the literature. Benign bone tumors have not previously been subjected to cytogenetic analysis. Analysis of this case revealed a primary abnormal clone trisomic for both chromosomes 3 and 5 and two subclones, one trisomic for chromosome 3 and one trisomic for chromosome 5. This case may also present the first description of nonrandom karyotic abnormalities in a benign neoplasm of bone.

Original languageEnglish (US)
Pages (from-to)272-278
Number of pages7
JournalClinical Orthopaedics and Related Research
Issue number247
StatePublished - 1989

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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