Detailed clinical and angiographic analysis of transluminal extraction coronary atherectomy for complex lesions in native coronary arteries

Robert D. Safian, Melissa A. May, Anne Lichtenberg, Theodore L. Schreiber, Gregory Pavlides, Thomas B. Meany, Cindy L. Grines, William W. O'Neill

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Objectives.: The purpose of this study was to describe the results of transluminal extraction coronary atherectomy in native coronary arteries. Background.: Transluminal extraction coronary atherectomy was approved by the Food and Drug Administration for use in native coronary arteries and vein grafts. Methods.: Between December 1988 and July 1992, transluminal extraction coronary atherectomy was performed in 181 native coronary arteries in 175 patients. A detailed angiographic and clinical assessment was performed. Results.: Quantitative angiography (mean ± SD) revealed an increase in minimal lumen diameter from 1.0 ± 0.6 mm before to 1.3 ± 0.7 mm after atherectomy, to 2.1 ± 0.8 mm after final treatment (p < 0.001), corresponding to a diameter stenosis of 70 ± 16%, 61 ± 21% and 36 ± 21%, respectively (p < 0.001). Final procedural success (final diameter stenosis <50%, no major complications) was achieved in 84%. Adjunctive angioplasty was used after atherectomy in 152 lesions (84%) to further enlarge lumen dimensions (130 lesions, 72%), salvage technical failures (2 lesions, 1%) and reverse atherectomy-induced abrupt closures (20 lesions, 11%). Clinical complications included death (2.3%), Q wave myocardial infarction (3.4%) and emergency bypass surgery (2.8%). The strongest independent correlate of major clinical complications was development of abrupt closure immediately after atherectomy (p = 0.01). Clinical follow-up of 92% of eligible patients revealed clinical restenosis (repeat intervention, late bypass surgery, myocardial infarction or death) in 28.5%. Angiographic follow-up of 83% of eligible lesions revealed a restenosis rate (diameter stenosis >50%) of 61%. Conclusions.: Transluminal extraction coronary atherectomy is limited by a modest degree of lumen enlargement, frequent need for adjunctive angioplasty and a high restenosis rate. For complex lesions in native coronary arteries, transluminal extraction coronary atherectomy appears to offer no advantage over conventional balloon angioplasty.

Original languageEnglish (US)
Pages (from-to)848-854
Number of pages7
JournalJournal of the American College of Cardiology
Issue number4
StatePublished - Mar 15 1995

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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