Detailed Deletion Mapping of Chromosome 6q in Borderline Epithelial Ovarian Tumors

Kerry J. Rodabaugh, Gayle Blanchard, Ross S. Berkowitz, Samuel C. Mok, William R. Welch, Debra A. Bell

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

We have used PCR amplification of tandem repeats and Southern blot analysis to study the pattern of allelic loss at chromosome 6q in borderline ovarian tumors and compared that with invasive ovarian carcinomas. DNA from 46 borderline ovarian tissues, 20 invasive ovarian tumor tissues, together with corresponding uninvolved (control) tissues was used. The invasive tumors demonstrated the highest percentage of loss of heterozygosity (13 of 45 informative cases, 29%) at the 6q25–27 locus site. In contrast, the borderline ovarian tumors showed only an 11% frequency of loss of heterozygosity (3 of 26). Our results display a sharp contrast in the pattern of loss of heterozygosity between invasive and borderline ovarian tumors and suggest that allelic loss at chromosome 6q may not be involved in the development of borderline ovarian tumors.

Original languageEnglish (US)
Pages (from-to)2169-2172
Number of pages4
JournalCancer Research
Volume55
Issue number10
StatePublished - May 15 1995

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Rodabaugh, K. J., Blanchard, G., Berkowitz, R. S., Mok, S. C., Welch, W. R., & Bell, D. A. (1995). Detailed Deletion Mapping of Chromosome 6q in Borderline Epithelial Ovarian Tumors. Cancer Research, 55(10), 2169-2172.