Detection of measles virus RNA in urine specimens from vaccine recipients

P. A. Rota, A. S. Khan, E. Durigon, T. Yuran, Y. S. Villamarzo, W. J. Bellini

Research output: Contribution to journalComment/debate

64 Scopus citations

Abstract

Analysis of urine specimens by using reverse transcriptase-PCR was evaluated as a rapid assay to identify individuals infected with measles virus. For the study, daily urine samples were obtained from either 15- month-old children or young adults following measles immunization. Overall, measles virus RNA was detected in 10 of 12 children during the 2-week sampling period. In some cases, measles virus RNA was detected as early as 1 day or as late as 14 days after vaccination. Measles virus RNA was also detected in the urine samples from all four of the young adults between 1 and 13 days after vaccination. This assay will enable continued studies of the shedding and transmission of measles virus and, it is hoped, will provide a rapid means to identify measles infection, especially in mild or asymptomatic cases.

Original languageEnglish (US)
Pages (from-to)2485-2488
Number of pages4
JournalJournal of clinical microbiology
Volume33
Issue number9
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • Microbiology (medical)

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