Detection of single walled carbon nanotube based sensors in a large mammal

Eric Hofferber, Jakob Meier, Nicolas Herrera, Joseph Stapleton, Chris Calkins, Nicole Iverson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

High resolution, rapid, and precise detection of biological analytes related to disease and infection is currently the focus of many researchers. Better biosensors could lead to earlier detection, more avenues of intervention, and higher efficacy of therapeutics, which would lead to better outcomes for all patients. One class of biosensors, single walled carbon nanotubes, is unique due to their nanoscale resolution, single molecule sensitivity, and reversibility for long term applications. While these biosensors have been successful in rodent models, to date, no study has shown successful sensor detection in a large animal. In this study, we show the first successful signal detection of single walled carbon nanotube-based sensors in a large mammal model. Using a relatively simple and cost-effective system, we were able to detect signals in nearly 70% of the sheep used in the study, marking an important steppingstone towards the use of SWNT-based sensors for clinical diagnostics.

Original languageEnglish (US)
Article number102489
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume40
DOIs
StatePublished - Feb 2022

Keywords

  • Biosensors
  • Carbon nanotubes
  • In vivo
  • Large animal model
  • Near infrared fluorescence

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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