TY - JOUR
T1 - Detection of single walled carbon nanotube based sensors in a large mammal
AU - Hofferber, Eric
AU - Meier, Jakob
AU - Herrera, Nicolas
AU - Stapleton, Joseph
AU - Calkins, Chris
AU - Iverson, Nicole
N1 - Funding Information:
The authors would like to thank the University of Nebraska Lincoln's Institutional Animal Care Program members, especially Kelly Heath and Craig Kreikemeirer-Bower, for their assistance in planning and performing the surgical procedures. We thank the Biological Systems Engineering Department and Animal Science Department for funding graduate students that completed this work. Funding for the animals in this study was provided from discretionary funds available to author Chris Calkins. Disclosures Conflict of interest: All the authors of aforesaid communication article hereby declare no conflict of interest for its publishing. Organizations that have funded the research: We thank the Biological Systems Engineering Department and Animal Science Department for funding graduate students that completed this work. Funding for the animals in this study was provided from discretionary funds available to author Chris Calkins.
Funding Information:
Organizations that have funded the research: We thank the Biological Systems Engineering Department and Animal Science Department for funding graduate students that completed this work. Funding for the animals in this study was provided from discretionary funds available to author Chris Calkins.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2022/2
Y1 - 2022/2
N2 - High resolution, rapid, and precise detection of biological analytes related to disease and infection is currently the focus of many researchers. Better biosensors could lead to earlier detection, more avenues of intervention, and higher efficacy of therapeutics, which would lead to better outcomes for all patients. One class of biosensors, single walled carbon nanotubes, is unique due to their nanoscale resolution, single molecule sensitivity, and reversibility for long term applications. While these biosensors have been successful in rodent models, to date, no study has shown successful sensor detection in a large animal. In this study, we show the first successful signal detection of single walled carbon nanotube-based sensors in a large mammal model. Using a relatively simple and cost-effective system, we were able to detect signals in nearly 70% of the sheep used in the study, marking an important steppingstone towards the use of SWNT-based sensors for clinical diagnostics.
AB - High resolution, rapid, and precise detection of biological analytes related to disease and infection is currently the focus of many researchers. Better biosensors could lead to earlier detection, more avenues of intervention, and higher efficacy of therapeutics, which would lead to better outcomes for all patients. One class of biosensors, single walled carbon nanotubes, is unique due to their nanoscale resolution, single molecule sensitivity, and reversibility for long term applications. While these biosensors have been successful in rodent models, to date, no study has shown successful sensor detection in a large animal. In this study, we show the first successful signal detection of single walled carbon nanotube-based sensors in a large mammal model. Using a relatively simple and cost-effective system, we were able to detect signals in nearly 70% of the sheep used in the study, marking an important steppingstone towards the use of SWNT-based sensors for clinical diagnostics.
KW - Biosensors
KW - Carbon nanotubes
KW - In vivo
KW - Large animal model
KW - Near infrared fluorescence
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U2 - 10.1016/j.nano.2021.102489
DO - 10.1016/j.nano.2021.102489
M3 - Article
C2 - 34740870
AN - SCOPUS:85120499581
SN - 1549-9634
VL - 40
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
M1 - 102489
ER -