Determinants of ten-year overall survival of acute myeloid leukemia: a large national cancer database analysis

Nabin Khanal, Valerie Shostrom, Prajwal Dhakal, Shristi Upadhyay Banskota, Chakra Chaulagain, Fiona He, Kailash Mosalpuria, Krishna Gundabolu, Vijaya Raj Bhatt

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Clinical trials do not routinely capture long-term overall survival (OS) in acute myeloid leukemia (AML). We utilized a large National Cancer Database (NCDB) to determine different factors affecting 10-year OS in AML. For patients, 18–59 years who were treated with chemotherapy only without upfront hematopoietic cell transplant (HCT), younger age, female, CBF AML, higher income, and private insurance conferred higher 10-year OS. Among patients, 18–59 years treated with chemotherapy and upfront HCT, younger age and private insurance conferred higher 10-year OS. In a Cox proportional hazard model, the likelihood of death decreased with younger age, fewer comorbidities, treatment at an academic center, private insurance, and use of multiagent chemotherapy. Our results demonstrate poor long-term OS even among younger patients and highlights disparities in leukemia care based on insurance type.

Original languageEnglish (US)
Pages (from-to)939-945
Number of pages7
JournalLeukemia and Lymphoma
Volume63
Issue number4
DOIs
StatePublished - 2022

Keywords

  • Acute myeloid leukemia
  • chemotherapy
  • leukemia
  • overall survival
  • transplant
  • younger age

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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