Abstract
An LC-MS method using APCI has been developed and validated for the determination of the anticancer drug vincristine in human plasma, using vinblastine as internal standard. Following solid-phase extraction (SPE) of the sample, the lower limit of quantitation (LLOQ) was 0.18 ng/ml, the lower limit of detection was 0.09 ng/ml, and the linear calibration range was 0.18-180 ng/ml. This method has been used to measure plasma concentrations of vincristine from 0.08 to 24 h post bolus in 29 infants as part of a pharmacokinetic study. Concentrations of vincristine at 24 h were 0.2-1.36 ng/ml.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 540-543 |
| Number of pages | 4 |
| Journal | Journal of Pharmaceutical and Biomedical Analysis |
| Volume | 41 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 3 2006 |
Keywords
- APCI
- Analysis
- Infant
- LC-MS
- Pediatric
- Plasma
- Vinblastine
- Vincristine
- Vinorelbine
ASJC Scopus subject areas
- Analytical Chemistry
- Pharmaceutical Science
- Drug Discovery
- Spectroscopy
- Clinical Biochemistry
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Cite this
Schmidt, M. S., Huang, R., Classon, R. J., & Murry, D. J. (2006). Determination of vincristine in infant plasma by liquid chromatography-atmospheric pressure chemical ionization-mass spectroscopy. Journal of Pharmaceutical and Biomedical Analysis, 41(2), 540-543. https://doi.org/10.1016/j.jpba.2005.11.039