Development of a combined K -edge subtraction and fluorescence subtraction imaging system for small animals

Brian Bewer; Honglin Zhang; Ying Zhu; Limei Zhang; Graham N. George; Ingrid J. Pickering; Dean Chapman

doi:10.1063/1.2964120

Development of a combined K -edge subtraction and fluorescence subtraction imaging system for small animals

Brian Bewer, Honglin Zhang, Ying Zhu, Limei Zhang, Graham N. George, Ingrid J. Pickering, Dean Chapman

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A novel combined imaging system for small animals using dilute concentrations of iodine as a contrast agent was developed for wide and pencil photon beam image acquisitions. This combined imaging system used K -edge subtraction (KES) and fluorescence subtraction imaging (FSI) and was tested at the Hard x-ray Microanalysis beamline at the Canadian Light Source. The initial wide beam KES image acquired with a charge-coupled device camera was used to identify regions of interest for further investigation and determine the location and area of the raster scan for pencil beam imaging. The pencil photon beam scanning mode acquired simultaneously KES and FSI measurements with an ionization chamber measuring the KES data and a multielement germanium detector measuring the FSI data. A description of the system is given as well as preliminary results using an iodine test object.

Original language	English (US)
Article number	085102
Journal	Review of Scientific Instruments
Volume	79
Issue number	8
DOIs	https://doi.org/10.1063/1.2964120
State	Published - 2008
Externally published	Yes

ASJC Scopus subject areas

Instrumentation

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title = "Development of a combined K -edge subtraction and fluorescence subtraction imaging system for small animals",

abstract = "A novel combined imaging system for small animals using dilute concentrations of iodine as a contrast agent was developed for wide and pencil photon beam image acquisitions. This combined imaging system used K -edge subtraction (KES) and fluorescence subtraction imaging (FSI) and was tested at the Hard x-ray Microanalysis beamline at the Canadian Light Source. The initial wide beam KES image acquired with a charge-coupled device camera was used to identify regions of interest for further investigation and determine the location and area of the raster scan for pencil beam imaging. The pencil photon beam scanning mode acquired simultaneously KES and FSI measurements with an ionization chamber measuring the KES data and a multielement germanium detector measuring the FSI data. A description of the system is given as well as preliminary results using an iodine test object.",

author = "Brian Bewer and Honglin Zhang and Ying Zhu and Limei Zhang and George, {Graham N.} and Pickering, {Ingrid J.} and Dean Chapman",

note = "Funding Information: This work was financially supported by the Saskatchewan Health Research Foundation, the Natural Sciences and Engineering Research Council of Canada Discovery Grant program, the Canadian Institutes of Health Research Regional Partnership Program, and the Canada Research Chair program through the research chairs of Dean Chapman, Graham N. George, and Ingrid J. Pickering. The research described in this paper was performed at the Canadian Light Source, which is supported by NSERC, NRC, CIHR, and the University of Saskatchewan. ",

year = "2008",

doi = "10.1063/1.2964120",

language = "English (US)",

volume = "79",

journal = "Review of Scientific Instruments",

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AU - Bewer, Brian

AU - Zhang, Honglin

AU - Zhu, Ying

AU - Zhang, Limei

AU - George, Graham N.

AU - Pickering, Ingrid J.

AU - Chapman, Dean

N1 - Funding Information: This work was financially supported by the Saskatchewan Health Research Foundation, the Natural Sciences and Engineering Research Council of Canada Discovery Grant program, the Canadian Institutes of Health Research Regional Partnership Program, and the Canada Research Chair program through the research chairs of Dean Chapman, Graham N. George, and Ingrid J. Pickering. The research described in this paper was performed at the Canadian Light Source, which is supported by NSERC, NRC, CIHR, and the University of Saskatchewan.

PY - 2008

Y1 - 2008

N2 - A novel combined imaging system for small animals using dilute concentrations of iodine as a contrast agent was developed for wide and pencil photon beam image acquisitions. This combined imaging system used K -edge subtraction (KES) and fluorescence subtraction imaging (FSI) and was tested at the Hard x-ray Microanalysis beamline at the Canadian Light Source. The initial wide beam KES image acquired with a charge-coupled device camera was used to identify regions of interest for further investigation and determine the location and area of the raster scan for pencil beam imaging. The pencil photon beam scanning mode acquired simultaneously KES and FSI measurements with an ionization chamber measuring the KES data and a multielement germanium detector measuring the FSI data. A description of the system is given as well as preliminary results using an iodine test object.

AB - A novel combined imaging system for small animals using dilute concentrations of iodine as a contrast agent was developed for wide and pencil photon beam image acquisitions. This combined imaging system used K -edge subtraction (KES) and fluorescence subtraction imaging (FSI) and was tested at the Hard x-ray Microanalysis beamline at the Canadian Light Source. The initial wide beam KES image acquired with a charge-coupled device camera was used to identify regions of interest for further investigation and determine the location and area of the raster scan for pencil beam imaging. The pencil photon beam scanning mode acquired simultaneously KES and FSI measurements with an ionization chamber measuring the KES data and a multielement germanium detector measuring the FSI data. A description of the system is given as well as preliminary results using an iodine test object.

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JF - Review of Scientific Instruments

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Development of a combined K -edge subtraction and fluorescence subtraction imaging system for small animals

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