TY - JOUR
T1 - Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders
AU - Eggert, Dawn
AU - Dash, Prasanta K.
AU - Serradji, Nawal
AU - Dong, Chang Zhi
AU - Clayette, Pascal
AU - Heymans, Francoise
AU - Dou, Huanyu
AU - Gorantla, Santhi
AU - Gelbard, Harris A.
AU - Poluektova, Larisa
AU - Gendelman, Howard E.
N1 - Funding Information:
We thank Ms. Robin Taylor for outstanding administrative and computer support and Nan Gong for MCN isolations and culture. The support of Michael Jacobson and Janice A. Taylor for confocal microscopy is much appreciated. National Institute of Health grants P01MH645702, R37 NS36126, P01 NS31492, 2R01 NS034239, P20RR 15635, P20RR 21937, P20 DA026146 and P01 NS43985 supported this work.
PY - 2009/8/18
Y1 - 2009/8/18
N2 - The neuroregulatory activities of PMS-601, a platelet activating factor antagonist, were investigated in laboratory and animal models of HIV-1 encephalitis (HIVE). For the former, PMS-601 reduced monocyte-derived macrophage pro-inflammatory secretions, multinucleated giant cell (MGC) formation, and neuronal loss independent of antiretroviral responses. PMS-601 treatment of HIVE severe combined immunodeficient mice showed reduced microgliosis, MGCs and neurodegeneration. These observations support the further development of PMS-601 as an adjunctive therapy for HIV-1 associated neurocognitive disorders.
AB - The neuroregulatory activities of PMS-601, a platelet activating factor antagonist, were investigated in laboratory and animal models of HIV-1 encephalitis (HIVE). For the former, PMS-601 reduced monocyte-derived macrophage pro-inflammatory secretions, multinucleated giant cell (MGC) formation, and neuronal loss independent of antiretroviral responses. PMS-601 treatment of HIVE severe combined immunodeficient mice showed reduced microgliosis, MGCs and neurodegeneration. These observations support the further development of PMS-601 as an adjunctive therapy for HIV-1 associated neurocognitive disorders.
KW - Human immunodeficiency virus
KW - Multinucleated giant cell
KW - Nuclear factor kappa beta
KW - PMS-601
KW - Platelet activating factor
KW - Proline-rich tyrosine kinase 2
UR - http://www.scopus.com/inward/record.url?scp=68149166882&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68149166882&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2009.06.002
DO - 10.1016/j.jneuroim.2009.06.002
M3 - Article
C2 - 19541372
AN - SCOPUS:68149166882
SN - 0165-5728
VL - 213
SP - 47
EP - 59
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
IS - 1-2
ER -