TY - JOUR
T1 - Development of a porous layer-by-layer microsphere with branched aliphatic hydrocarbon porogens
AU - Shahjin, Farah
AU - Patel, Milankumar
AU - Hasan, Mahmudul
AU - Cohen, Jacob D.
AU - Islam, Farhana
AU - Ashaduzzaman, Md
AU - Nayan, Mohammad Ullah
AU - Subramaniam, Mahadevan
AU - Zhou, You
AU - Andreu, Irene
AU - Gendelman, Howard E.
AU - Kevadiya, Bhavesh D.
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2023/2
Y1 - 2023/2
N2 - Porous polymer microspheres are employed in biotherapeutics, tissue engineering, and regenerative medicine. Porosity dictates cargo carriage and release that are aligned with the polymer physicochemical properties. These include material tuning, biodegradation, and cargo encapsulation. How uniformity of pore size affects therapeutic delivery remains an area of active investigation. Herein, we characterize six branched aliphatic hydrocarbon-based porogen(s) produced to create pores in single and multilayered microspheres. The porogens are composed of biocompatible polycaprolactone, poly(lactic-co-glycolic acid), and polylactic acid polymers within porous multilayered microspheres. These serve as controlled effective drug and vaccine delivery platforms.
AB - Porous polymer microspheres are employed in biotherapeutics, tissue engineering, and regenerative medicine. Porosity dictates cargo carriage and release that are aligned with the polymer physicochemical properties. These include material tuning, biodegradation, and cargo encapsulation. How uniformity of pore size affects therapeutic delivery remains an area of active investigation. Herein, we characterize six branched aliphatic hydrocarbon-based porogen(s) produced to create pores in single and multilayered microspheres. The porogens are composed of biocompatible polycaprolactone, poly(lactic-co-glycolic acid), and polylactic acid polymers within porous multilayered microspheres. These serve as controlled effective drug and vaccine delivery platforms.
KW - Layer-by-layer
KW - Poly(glycolide-co-lactide)
KW - Poly(ε-caprolactone)
KW - Polylactide
KW - Porogens
KW - Porous microspheres
KW - Solvent evaporation
UR - http://www.scopus.com/inward/record.url?scp=85145255367&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85145255367&partnerID=8YFLogxK
U2 - 10.1016/j.nano.2022.102644
DO - 10.1016/j.nano.2022.102644
M3 - Article
C2 - 36549555
AN - SCOPUS:85145255367
SN - 1549-9634
VL - 48
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
M1 - 102644
ER -