TY - JOUR
T1 - Development of a porous layer-by-layer microsphere with branched aliphatic hydrocarbon porogens
AU - Shahjin, Farah
AU - Patel, Milankumar
AU - Hasan, Mahmudul
AU - Cohen, Jacob D.
AU - Islam, Farhana
AU - Ashaduzzaman, Md
AU - Nayan, Mohammad Ullah
AU - Subramaniam, Mahadevan
AU - Zhou, You
AU - Andreu, Irene
AU - Gendelman, Howard E.
AU - Kevadiya, Bhavesh D
N1 - Funding Information:
The authors acknowledge the support provided by Tom Barger and Nicholas Conoan of the Electron Microscopy Core Facility (EMCF) at the University of Nebraska Medical Center for technical assistance. The EMCF is supported by state funds from the Nebraska Research Initiative (NRI) and the University of Nebraska Foundation and institutionally by the Office of the Vice Chancellor for Research; Terri Fangman for the confocal spectral analysis work at the Microscopy Core Research Facility of Center for Biotechnology at the University of Nebraska-Lincoln, supported by NIH, CIBC, COBRE grant P20 GM113126, NIGMS; Drs. Shah Valloppilly, Lanping Yue of Nebraska Nanoscale Facility: National Nanotechnology Coordinated Infrastructure and the Nebraska Center for Materials and Nanoscience for the XPS, XRD, DSC, TGA measurements, which are supported by the National Science Foundation under Award ECCS-2025298, the Nebraska Research Initiative (NRI); the RI Consortium for Nanoscience and Nanotechnology, a URI College of Engineering core facility for the confocal Raman microscope, the X-ray microscope data acquisition which was partially funded by the National Science Foundation EPSCoR, Cooperative Agreement # OIA-1655221 , Primary funding support was by National Institutes of Health grants R01 NS034239 ; T32 NS105594 ; R01 NS036126 ; R01 MH115860 ; R01 NS126089 ; R01 AI145542 ; R01 AI158160 ; and MH121402 . The X-ray microscope was acquired through RI Innovation Campus funds by the Rhode Island Commerce Corporation to 401 Tech Bridge and the URI Research Foundation. Some of the figure panels were made with BioRender.com . This publication's contents are the sole responsibility of the authors and do not represent the official views of the funding agencies.
Funding Information:
Funding sources: This work was supported by National Institutes of Health grants R01 MH121402-01A1 , R01 MH128009-01 , P01 DA028555-06A1 and by the Nebraska Neuroscience Alliance and University of Nebraska graduate studies assistantships. The funding authorities did not participate in any part of the experimental design, execution, or data analysis.
Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2023/2
Y1 - 2023/2
N2 - Porous polymer microspheres are employed in biotherapeutics, tissue engineering, and regenerative medicine. Porosity dictates cargo carriage and release that are aligned with the polymer physicochemical properties. These include material tuning, biodegradation, and cargo encapsulation. How uniformity of pore size affects therapeutic delivery remains an area of active investigation. Herein, we characterize six branched aliphatic hydrocarbon-based porogen(s) produced to create pores in single and multilayered microspheres. The porogens are composed of biocompatible polycaprolactone, poly(lactic-co-glycolic acid), and polylactic acid polymers within porous multilayered microspheres. These serve as controlled effective drug and vaccine delivery platforms.
AB - Porous polymer microspheres are employed in biotherapeutics, tissue engineering, and regenerative medicine. Porosity dictates cargo carriage and release that are aligned with the polymer physicochemical properties. These include material tuning, biodegradation, and cargo encapsulation. How uniformity of pore size affects therapeutic delivery remains an area of active investigation. Herein, we characterize six branched aliphatic hydrocarbon-based porogen(s) produced to create pores in single and multilayered microspheres. The porogens are composed of biocompatible polycaprolactone, poly(lactic-co-glycolic acid), and polylactic acid polymers within porous multilayered microspheres. These serve as controlled effective drug and vaccine delivery platforms.
KW - Layer-by-layer
KW - Poly(glycolide-co-lactide)
KW - Poly(ε-caprolactone)
KW - Polylactide
KW - Porogens
KW - Porous microspheres
KW - Solvent evaporation
UR - http://www.scopus.com/inward/record.url?scp=85145255367&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85145255367&partnerID=8YFLogxK
U2 - 10.1016/j.nano.2022.102644
DO - 10.1016/j.nano.2022.102644
M3 - Article
C2 - 36549555
AN - SCOPUS:85145255367
SN - 1549-9634
VL - 48
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
M1 - 102644
ER -