Development of a rapid autopsy program for studies of brain immunity

Anuja Ghorpade, Leslie Bruch, Yuri Persidsky, Betty Chin, William H.C. Brown, Kathleen Borgmann, Raisa Persidsky, Li Wu, Spring Holter, Robin Cotter, Jill Faraci, David Heilman, Vakara Meyer, Jane F. Potter, Susan Swindells, Howard E. Gendelman

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Human glia are essential cellular models used for studies of neurodegenerative diseases. Fetal neuroglia are commonly used, as they can be recovered in large quantities and sustained for long periods in culture. However, fetal neuroglia may have limitations in reflecting adult diseases and additionally can pose ethical issues in translating products of abortion for research use. To address these concerns, we developed a rapid autopsy program to procure age- and disease-specific neuroglia from adult brain tissues within hours of death. The challenges in developing this initiative, reflecting experiences from 69 autopsies over 4 years, are presented.

Original languageEnglish (US)
Pages (from-to)135-144
Number of pages10
JournalJournal of Neuroimmunology
Volume163
Issue number1-2
DOIs
StatePublished - Jun 2005

Keywords

  • Inflammation
  • Microglia
  • Neurodegenerative diseases
  • Rapid autopsy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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  • Cite this

    Ghorpade, A., Bruch, L., Persidsky, Y., Chin, B., Brown, W. H. C., Borgmann, K., Persidsky, R., Wu, L., Holter, S., Cotter, R., Faraci, J., Heilman, D., Meyer, V., Potter, J. F., Swindells, S., & Gendelman, H. E. (2005). Development of a rapid autopsy program for studies of brain immunity. Journal of Neuroimmunology, 163(1-2), 135-144. https://doi.org/10.1016/j.jneuroim.2005.01.021