TY - GEN
T1 - Development of an in vitro traumatic brain injury model using 3d cultured neural stem cells and 3d printed device
AU - Shi, Wen
AU - Kuss, Mitchell A.
AU - Dong, Pengfei
AU - Gu, Linxia
AU - Kim, Hyung Joon
AU - Duan, Bin
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: Traumatic brain injury (TBI), which always causes great brain dysfunction and even mortality to the victims, is normally modeled in animals. Recently the development of in vitro models has been helped to investigate the pathophysiological mechanism behind the mechanical impact to the brain. However, most of the in vitro models are based on 2D cell culture and could not represent the real situation. Here, we developed an in vitro model of TBI using the 3D cultured neural stem cells and a 3D printed impact device and evaluated the effect of impact strength and frequency on apoptosis, proliferation, differentiation, maturation, and phenotypes of neural stem cells and glia cells.
AB - Statement of Purpose: Traumatic brain injury (TBI), which always causes great brain dysfunction and even mortality to the victims, is normally modeled in animals. Recently the development of in vitro models has been helped to investigate the pathophysiological mechanism behind the mechanical impact to the brain. However, most of the in vitro models are based on 2D cell culture and could not represent the real situation. Here, we developed an in vitro model of TBI using the 3D cultured neural stem cells and a 3D printed impact device and evaluated the effect of impact strength and frequency on apoptosis, proliferation, differentiation, maturation, and phenotypes of neural stem cells and glia cells.
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M3 - Conference contribution
AN - SCOPUS:85065434315
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 620
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -