Development of an in vitro traumatic brain injury model using 3d cultured neural stem cells and 3d printed device

Wen Shi, Mitchell A. Kuss, Pengfei Dong, Linxia Gu, Hyung Joon Kim, Bin Duan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Traumatic brain injury (TBI), which always causes great brain dysfunction and even mortality to the victims, is normally modeled in animals. Recently the development of in vitro models has been helped to investigate the pathophysiological mechanism behind the mechanical impact to the brain. However, most of the in vitro models are based on 2D cell culture and could not represent the real situation. Here, we developed an in vitro model of TBI using the 3D cultured neural stem cells and a 3D printed impact device and evaluated the effect of impact strength and frequency on apoptosis, proliferation, differentiation, maturation, and phenotypes of neural stem cells and glia cells.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages620
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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