Development of functional poly(amido amine) CXCR4 antagonists with the ability to mobilize leukocytes and deliver nucleic acids

Yan Wang, Stuart T. Hazeldine, Jing Li, David Oupický

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

CXCR4 chemokine receptor plays a crucial role in metastatic spread of multiple types of cancer. The present study reports on synthesis of functional polymers based on newly synthesized CXCR4-inhibiting monomers. The resultant linear polymeric CXCR4 antagonists (PCX) show improved ability to inhibit CXCR4 when compared with the monomers. The CXCR4 antagonism provides PCX with the ability to mobilize leukocytes from bone marrow to peripheral blood and to inhibit cancer cell invasion. Due to their cationic nature, PCX can form polyplexes with DNA and mediate efficient transfection. The reported findings validate PCX as promising dual-function polymeric drugs that can deliver therapeutic nucleic acids and improve cancer therapy by simultaneously inhibiting CXCR4 chemokine receptor.

Original languageEnglish (US)
Pages (from-to)729-738
Number of pages10
JournalAdvanced Healthcare Materials
Volume4
Issue number5
DOIs
StatePublished - Apr 1 2015

Keywords

  • Chemokine receptors
  • Gene delivery
  • Polycation
  • Polyplexes

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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