Development of luminescent Mycobacterium avium subsp. paratuberculosis for rapid screening of vaccine candidates in mice

Valérie Rosseeis, Virginie Roupie, Denise Zinniel, Raúl G. Barletta, Kris Huygen

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Mycobacterium avium subsp. paratuberculosis is a slowly growing mycobacterial species, requiring 6 to 8 weeks of culture before colonies can be counted visually. Here, we describe the development of luminescent M. avium subsp. paratuberculosis expressing luxAB genes of Vibrio harveyi and its use for vaccine testing in an experimental-mouse model, replacing fastidious CFU counting by rapid luminometry.

Original languageEnglish (US)
Pages (from-to)3684-3686
Number of pages3
JournalInfection and immunity
Volume74
Issue number6
DOIs
StatePublished - Jun 2006

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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