The effect of dexamethasone on α-fetoprotein gene expression was studied in newborn mice. The treatment of 3 day old mice with 1 μg/gm body weight of dexamethasone twice a day reduced the α-fetoprotein level in serum to about 2.5% of the normal control level after 4 days of administration. The level of α-fetoprotein mRNA sequences in the cytoplasm decreased to about 1% of the control over this same period. Furthermore, only an extremely low concentration of α-fetoprotein mRNA sequences in nuclear RNA could be detected even at a high Crot. These results suggest that dexamethasone inhibits transcription of the α-fetoprotein gene in newborn mice.
|Original language||English (US)|
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Aug 28 1979|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology