Dexamethasone inhibits α-fetoprotein gene expression in developing mouse liver

Patricia Commer, Charles Schwartz, Steven Tracy, Taiki Tamaoki, Jen Fu Chiu

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The effect of dexamethasone on α-fetoprotein gene expression was studied in newborn mice. The treatment of 3 day old mice with 1 μg/gm body weight of dexamethasone twice a day reduced the α-fetoprotein level in serum to about 2.5% of the normal control level after 4 days of administration. The level of α-fetoprotein mRNA sequences in the cytoplasm decreased to about 1% of the control over this same period. Furthermore, only an extremely low concentration of α-fetoprotein mRNA sequences in nuclear RNA could be detected even at a high Crot. These results suggest that dexamethasone inhibits transcription of the α-fetoprotein gene in newborn mice.

Original languageEnglish (US)
Pages (from-to)1294-1299
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume89
Issue number4
DOIs
StatePublished - Aug 28 1979

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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