Diabetes and COVID-19 risk: an miRNA perspective

Paras K. Mishra, Ritesh Tandon, Siddappa N. Byrareddy

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Coronavirus disease 2019 (COVID-19) and diabetes outcomes (CORONADO) trial revealed that 10.6% of patients with diabetes mellitus hospitalized for COVID-19 (COVID-19) die within 7 days. Several studies from New York, Italy, and China confirm that patients with diabetes are at a much higher risk for mortality due to COVID-19. Besides respiratory illness, COVID-19 increases cardiac injury and diabetic ketoacidosis. In the absence of specific guidelines for the prevention and treatment of COVID-19 for patients with diabetes, they remain at higher risk and are more susceptible to COVID-19. Furthermore, there is a scarcity of basic knowledge on how diabetes affects pathogenesis of severe acute respiratory coronavirus (SARSCoV-2) infection. In patients with diabetes, impaired glucose use alters metabolic and consequently biological processes instigating pathological remodeling, which has detrimental effects on cardiovascular systems. A majority of biological processes are regulated by noncoding microRNAs (miRNAs), which have emerged as a promising therapeutic candidate for several diseases. In consideration of the higher risk of mortality in patients with diabetes and COVID-19, novel diagnostic test and treatment strategy are urgently warranted in post-COVID-19 era. Here, we describe potential roles of miRNA as a biomarker and therapeutic candidate, especially for heart failure, in patients with diabetes and COVID-19.

Original languageEnglish (US)
Pages (from-to)H604-H609
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume319
Issue number3
DOIs
StatePublished - Sep 2020

Keywords

  • Biomarker
  • Cardiovascular disease
  • Heart failure
  • Noncoding RNA
  • SARS-CoV-2
  • Therapeutic candidate

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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