Diabetic and Galactosaemic Cataracts

Peter F. Kador, Jin H. Kinoshita

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

An increased prevalence of cataract is associated with diabetes. Biochemical studies of diabetic lenses have revealed a variety of metabolic abnormalities including changes in the levels of electrolytes, glutathione, nucleotides and sugars. Similar biochemical changes have also been observed in cataracts associated with galactosaemia. suggesting that these sugar cataracts have a common biochemical aetiology. The common biochemical factor found to initiate both types of sugar cataract is the formation of sugar alcohols (polyols) from either glucose or galactose by the enzyme aldose reductase (alditol: NADP- I-oxidoreductase. EC 1.1.1.21) Increased intracellular levels of these polar alcohols have a hyperosmotic effect which leads to lens fibre swelling. vacuole formation and subsequent opacification. The process of sugar cataract formation in animals can be prevented by inhibiting aldose reductase.

Original languageEnglish (US)
Title of host publicationHuman Cataract Formation
PublisherWiley-Blackwell
Pages110-131
Number of pages22
ISBN (Electronic)9780470720875
ISBN (Print)0272797758, 9780272797754
DOIs
StatePublished - May 30 2008

Keywords

  • Biochemical studies
  • Diabetic cataracts
  • Galactosaemia
  • Galactosaemic cataracts
  • Metabolic abnormalities

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Diabetic and Galactosaemic Cataracts'. Together they form a unique fingerprint.

Cite this