Diagnosis and management of a malignant granulosa cell tumor in a holstein nulligravida: A case study

D. E. Hostetler; D. J. Sprecher; B. Yamini; N. K. Ames

doi:10.1016/S0093-691X(97)00188-X

Diagnosis and management of a malignant granulosa cell tumor in a holstein nulligravida: A case study

D. E. Hostetler, D. J. Sprecher, B. Yamini, N. K. Ames

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Transrectal palpation of an 18-mo-old, anestrous Holstein nulligravida revealed an enlarged left ovary. Ultrasonographically, the mass resembled known equine granulosa cell tumor (GCT) images. Slowly, virilism developed. Fifty-five days after initial diagnosis, unilateral ovariectomy was performed. The presurgical serum concentration of testosterone was equal to that of a mature bull. During the 3 mo period following surgery, estrus expression resumed, the serum testosterone concentration returned to baseline, and the heifer was diagnosed pregnant following AI. A low grade, malignant GCT was the final histopathologically diagnosis. Clinical diagnosis of GCT should involve ultrasonography and steroid hormone assay. An ultrasound image, similar to the one shown, may be characteristic of GCT in the bovine.

Original language	English (US)
Pages (from-to)	11-17
Number of pages	7
Journal	Theriogenology
Volume	48
Issue number	1
DOIs	https://doi.org/10.1016/S0093-691X(97)00188-X
State	Published - Jul 1 1997
Externally published	Yes

Keywords

Bovine
Granulosa cell tumor
Malignant
Nulligravida
Testosterone

ASJC Scopus subject areas

Small Animals
Food Animals
Animal Science and Zoology
Equine

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10.1016/S0093-691X(97)00188-X

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title = "Diagnosis and management of a malignant granulosa cell tumor in a holstein nulligravida: A case study",

abstract = "Transrectal palpation of an 18-mo-old, anestrous Holstein nulligravida revealed an enlarged left ovary. Ultrasonographically, the mass resembled known equine granulosa cell tumor (GCT) images. Slowly, virilism developed. Fifty-five days after initial diagnosis, unilateral ovariectomy was performed. The presurgical serum concentration of testosterone was equal to that of a mature bull. During the 3 mo period following surgery, estrus expression resumed, the serum testosterone concentration returned to baseline, and the heifer was diagnosed pregnant following AI. A low grade, malignant GCT was the final histopathologically diagnosis. Clinical diagnosis of GCT should involve ultrasonography and steroid hormone assay. An ultrasound image, similar to the one shown, may be characteristic of GCT in the bovine.",

keywords = "Bovine, Granulosa cell tumor, Malignant, Nulligravida, Testosterone",

author = "Hostetler, {D. E.} and Sprecher, {D. J.} and B. Yamini and Ames, {N. K.}",

note = "Funding Information: Acknowledgments The authors thank the Department of Large Animal Clinical Sciences for financial support aCorrespondence and reprint requests",

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AU - Hostetler, D. E.

AU - Sprecher, D. J.

AU - Yamini, B.

AU - Ames, N. K.

N1 - Funding Information: Acknowledgments The authors thank the Department of Large Animal Clinical Sciences for financial support aCorrespondence and reprint requests

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Y1 - 1997/7/1

N2 - Transrectal palpation of an 18-mo-old, anestrous Holstein nulligravida revealed an enlarged left ovary. Ultrasonographically, the mass resembled known equine granulosa cell tumor (GCT) images. Slowly, virilism developed. Fifty-five days after initial diagnosis, unilateral ovariectomy was performed. The presurgical serum concentration of testosterone was equal to that of a mature bull. During the 3 mo period following surgery, estrus expression resumed, the serum testosterone concentration returned to baseline, and the heifer was diagnosed pregnant following AI. A low grade, malignant GCT was the final histopathologically diagnosis. Clinical diagnosis of GCT should involve ultrasonography and steroid hormone assay. An ultrasound image, similar to the one shown, may be characteristic of GCT in the bovine.

AB - Transrectal palpation of an 18-mo-old, anestrous Holstein nulligravida revealed an enlarged left ovary. Ultrasonographically, the mass resembled known equine granulosa cell tumor (GCT) images. Slowly, virilism developed. Fifty-five days after initial diagnosis, unilateral ovariectomy was performed. The presurgical serum concentration of testosterone was equal to that of a mature bull. During the 3 mo period following surgery, estrus expression resumed, the serum testosterone concentration returned to baseline, and the heifer was diagnosed pregnant following AI. A low grade, malignant GCT was the final histopathologically diagnosis. Clinical diagnosis of GCT should involve ultrasonography and steroid hormone assay. An ultrasound image, similar to the one shown, may be characteristic of GCT in the bovine.

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Diagnosis and management of a malignant granulosa cell tumor in a holstein nulligravida: A case study

Abstract

Keywords

ASJC Scopus subject areas

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